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Light‐Controllable Binary Switch Activation of CAR T Cells

Major challenges to chimeric antigen receptor (CAR) T cell therapies include uncontrolled immune activity, off‐tumor toxicities and tumor heterogeneity. To overcome these challenges, we engineered CARs directed against small molecules. By conjugating the same small molecule to distinct tumor‐targeti...

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Detalles Bibliográficos
Autores principales:	Kobayashi, Aya, Nobili, Alberto, Neier, Steven C., Sadiki, Amissi, Distel, Robert, Zhou, Zhaohui Sunny, Novina, Carl D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304291/ https://www.ncbi.nlm.nih.gov/pubmed/35146940 http://dx.doi.org/10.1002/cmdc.202100722

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