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Amygdala and subregion volumes are associated with photoperiod and seasonal depressive symptoms: A cross‐sectional study in the UK Biobank cohort

Although seasonal changes in amygdala volume have been demonstrated in animals, seasonal differences in human amygdala subregion volumes have yet to be investigated. Amygdala volume has also been linked to depressed mood. Therefore, we hypothesised that differences in photoperiod would predict diffe...

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Autores principales: Majrashi, Naif A., Alyami, Ali S., Shubayr, Nasser A., Alenezi, Meshaal M., Waiter, Gordon D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304295/
https://www.ncbi.nlm.nih.gov/pubmed/35165958
http://dx.doi.org/10.1111/ejn.15624
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author Majrashi, Naif A.
Alyami, Ali S.
Shubayr, Nasser A.
Alenezi, Meshaal M.
Waiter, Gordon D.
author_facet Majrashi, Naif A.
Alyami, Ali S.
Shubayr, Nasser A.
Alenezi, Meshaal M.
Waiter, Gordon D.
author_sort Majrashi, Naif A.
collection PubMed
description Although seasonal changes in amygdala volume have been demonstrated in animals, seasonal differences in human amygdala subregion volumes have yet to be investigated. Amygdala volume has also been linked to depressed mood. Therefore, we hypothesised that differences in photoperiod would predict differences in amygdala or subregion volumes and that this association would be linked to depressed mood. 10,033 participants ranging in age from 45 to 79 years were scanned by MRI in a single location. Amygdala subregion volumes were obtained using automated processing and segmentation algorithms. A mediation analysis tested whether amygdala volume mediated the relationship between photoperiod and mood. Photoperiod was positively associated with total amygdala volume (p < .001). Multivariate (GLM) analyses revealed significant effects of photoperiod across all amygdala subregion volumes for both hemispheres (p < .001). Post hoc univariate regression analyses revealed significant associations of photoperiod with each amygdala subregion volume (p < .001). PLS showed the highest loadings of amygdala subregions in lateral nucleus, ABN, basal nucleus, CAT, PLN, AAA, central nucleus, cortical nucleus and medial nucleus for left hemisphere and ABN, lateral nucleus, CAT, PLN, cortical nucleus, AAA, central nucleus and medial nucleus for right hemisphere. There were no significant associations between photoperiod and mood nor between mood scores and amygdala volumes, and due to the lack of these associations, the mediation hypothesis was not supported. This study is the first to demonstrate an association between photoperiod and amygdala volume. These findings add to the evidence supporting the role of photoperiod on brain structural plasticity.
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spelling pubmed-93042952022-07-28 Amygdala and subregion volumes are associated with photoperiod and seasonal depressive symptoms: A cross‐sectional study in the UK Biobank cohort Majrashi, Naif A. Alyami, Ali S. Shubayr, Nasser A. Alenezi, Meshaal M. Waiter, Gordon D. Eur J Neurosci Clinical and Translational Neuroscience Although seasonal changes in amygdala volume have been demonstrated in animals, seasonal differences in human amygdala subregion volumes have yet to be investigated. Amygdala volume has also been linked to depressed mood. Therefore, we hypothesised that differences in photoperiod would predict differences in amygdala or subregion volumes and that this association would be linked to depressed mood. 10,033 participants ranging in age from 45 to 79 years were scanned by MRI in a single location. Amygdala subregion volumes were obtained using automated processing and segmentation algorithms. A mediation analysis tested whether amygdala volume mediated the relationship between photoperiod and mood. Photoperiod was positively associated with total amygdala volume (p < .001). Multivariate (GLM) analyses revealed significant effects of photoperiod across all amygdala subregion volumes for both hemispheres (p < .001). Post hoc univariate regression analyses revealed significant associations of photoperiod with each amygdala subregion volume (p < .001). PLS showed the highest loadings of amygdala subregions in lateral nucleus, ABN, basal nucleus, CAT, PLN, AAA, central nucleus, cortical nucleus and medial nucleus for left hemisphere and ABN, lateral nucleus, CAT, PLN, cortical nucleus, AAA, central nucleus and medial nucleus for right hemisphere. There were no significant associations between photoperiod and mood nor between mood scores and amygdala volumes, and due to the lack of these associations, the mediation hypothesis was not supported. This study is the first to demonstrate an association between photoperiod and amygdala volume. These findings add to the evidence supporting the role of photoperiod on brain structural plasticity. John Wiley and Sons Inc. 2022-02-19 2022-03 /pmc/articles/PMC9304295/ /pubmed/35165958 http://dx.doi.org/10.1111/ejn.15624 Text en © 2022 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Clinical and Translational Neuroscience
Majrashi, Naif A.
Alyami, Ali S.
Shubayr, Nasser A.
Alenezi, Meshaal M.
Waiter, Gordon D.
Amygdala and subregion volumes are associated with photoperiod and seasonal depressive symptoms: A cross‐sectional study in the UK Biobank cohort
title Amygdala and subregion volumes are associated with photoperiod and seasonal depressive symptoms: A cross‐sectional study in the UK Biobank cohort
title_full Amygdala and subregion volumes are associated with photoperiod and seasonal depressive symptoms: A cross‐sectional study in the UK Biobank cohort
title_fullStr Amygdala and subregion volumes are associated with photoperiod and seasonal depressive symptoms: A cross‐sectional study in the UK Biobank cohort
title_full_unstemmed Amygdala and subregion volumes are associated with photoperiod and seasonal depressive symptoms: A cross‐sectional study in the UK Biobank cohort
title_short Amygdala and subregion volumes are associated with photoperiod and seasonal depressive symptoms: A cross‐sectional study in the UK Biobank cohort
title_sort amygdala and subregion volumes are associated with photoperiod and seasonal depressive symptoms: a cross‐sectional study in the uk biobank cohort
topic Clinical and Translational Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304295/
https://www.ncbi.nlm.nih.gov/pubmed/35165958
http://dx.doi.org/10.1111/ejn.15624
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