Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration

Chaperone-mediated autophagy activity, essential in the cellular defense against proteotoxicity, declines with age, and preventing this decline in experimental genetic models has proven beneficial. Here, we have identified the mechanism of action of selective chaperone-mediated autophagy activators...

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Detalles Bibliográficos
Autores principales: Gomez-Sintes, Raquel, Xin, Qisheng, Jimenez-Loygorri, Juan Ignacio, McCabe, Mericka, Diaz, Antonio, Garner, Thomas P., Cotto-Rios, Xiomaris M., Wu, Yang, Dong, Shuxian, Reynolds, Cara A., Patel, Bindi, de la Villa, Pedro, Macian, Fernando, Boya, Patricia, Gavathiotis, Evripidis, Cuervo, Ana Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304322/
https://www.ncbi.nlm.nih.gov/pubmed/35864098
http://dx.doi.org/10.1038/s41467-022-31869-1

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