Etv2 regulates enhancer chromatin status to initiate Shh expression in the limb bud

Sonic hedgehog (Shh) is essential for limb development, and the mechanisms that govern the propagation and maintenance of its expression has been well studied; however, the mechanisms that govern the initiation of Shh expression are incomplete. Here we report that ETV2 initiates Shh expression by ch...

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Detalles Bibliográficos
Autores principales: Koyano-Nakagawa, Naoko, Gong, Wuming, Das, Satyabrata, Theisen, Joshua W. M., Swanholm, Tran B., Van Ly, Daniel, Dsouza, Nikita, Singh, Bhairab N., Kawakami, Hiroko, Young, Samantha, Chen, Katherine Q., Kawakami, Yasuhiko, Garry, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304341/
https://www.ncbi.nlm.nih.gov/pubmed/35864091
http://dx.doi.org/10.1038/s41467-022-31848-6

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