Activated amino acid response pathway generates apatinib resistance by reprograming glutamine metabolism in non-small-cell lung cancer

The efficacy of apatinib has been confirmed in the treatment of solid tumors, including non-small-cell lung cancer (NSCLC). However, the direct functional mechanisms of tumor lethality mediated by apatinib and the precise mechanisms of drug resistance are largely unknown. In this study, we demonstra...

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Detalles Bibliográficos
Autores principales: Zhou, Xiaoshu, Zhou, Rui, Rao, Xinrui, Hong, Jiaxin, Li, Qianwen, Jie, Xiaohua, Wang, Jian, Xu, Yingzhuo, Zhu, Kuikui, Li, Zhenyu, Wu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304404/
https://www.ncbi.nlm.nih.gov/pubmed/35864117
http://dx.doi.org/10.1038/s41419-022-05079-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304404/
https://www.ncbi.nlm.nih.gov/pubmed/35864117
http://dx.doi.org/10.1038/s41419-022-05079-y

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