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IL22RA1/JAK/STAT Signaling Acts As a Cancer Target Through Pan-Cancer Analysis

Cytokines and cytokine receptors are important mediators in immunity and cancer development. Interleukin 22 (IL22) is one of the most important cytokines which has protumor effect. Given that common and specific roles of cytokines/receptors in multiple cancers, we conducted a pan-cancer study to inv...

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Autores principales: Zhang, Shuai, Yang, Guiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304570/
https://www.ncbi.nlm.nih.gov/pubmed/35874683
http://dx.doi.org/10.3389/fimmu.2022.915246
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author Zhang, Shuai
Yang, Guiyan
author_facet Zhang, Shuai
Yang, Guiyan
author_sort Zhang, Shuai
collection PubMed
description Cytokines and cytokine receptors are important mediators in immunity and cancer development. Interleukin 22 (IL22) is one of the most important cytokines which has protumor effect. Given that common and specific roles of cytokines/receptors in multiple cancers, we conducted a pan-cancer study to investigate the role of IL22RA1 in cancer using The Cancer Genome Atlas (TCGA) database. Notably, we found IL22RA1 transcript was upregulated in 11 cancer types compared with their corresponding control. The mRNA expression level of IL22RA1 was highest in the pancreas among tumor tissues. The higher expression of IL22RA1 was associated with worse overall survival rate in patients. A total of 30 IL22RA1-correlated genes (e.g. IL17D, IL22RA2, IL20RB, IL10RA, IL10RB, TSLP and TYK2) are involved in the JAK/STAT pathway which promotes tumor progression. The upregulation of IL22RA1 in tumors was correlated with immune cell infiltration level. Higher expression of IL22RA2, IL20RB, IL10RA, IL10RB, TSLP, TYK2, STAT1 and STAT3 was associated with decreased overall survival rate in patients. IL22RA1 mutation was observed more in uterine cancer and melanoma compared with the other cancer types. Deactivation of IL22RA1 induced a lot of changes in gene expression. IL22RA1 mutants had upregulated DNA damage/repair genes in uterine cancer, whereas downregulated genes in the FoxO signaling pathway. In melanoma, mutation of IL22RA1 can upregulate the HIF signaling pathway but downregulate metabolic pathways. Our study suggests that IL22RA1/JAK/STAT signaling can be an important target for cancer treatment.
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spelling pubmed-93045702022-07-23 IL22RA1/JAK/STAT Signaling Acts As a Cancer Target Through Pan-Cancer Analysis Zhang, Shuai Yang, Guiyan Front Immunol Immunology Cytokines and cytokine receptors are important mediators in immunity and cancer development. Interleukin 22 (IL22) is one of the most important cytokines which has protumor effect. Given that common and specific roles of cytokines/receptors in multiple cancers, we conducted a pan-cancer study to investigate the role of IL22RA1 in cancer using The Cancer Genome Atlas (TCGA) database. Notably, we found IL22RA1 transcript was upregulated in 11 cancer types compared with their corresponding control. The mRNA expression level of IL22RA1 was highest in the pancreas among tumor tissues. The higher expression of IL22RA1 was associated with worse overall survival rate in patients. A total of 30 IL22RA1-correlated genes (e.g. IL17D, IL22RA2, IL20RB, IL10RA, IL10RB, TSLP and TYK2) are involved in the JAK/STAT pathway which promotes tumor progression. The upregulation of IL22RA1 in tumors was correlated with immune cell infiltration level. Higher expression of IL22RA2, IL20RB, IL10RA, IL10RB, TSLP, TYK2, STAT1 and STAT3 was associated with decreased overall survival rate in patients. IL22RA1 mutation was observed more in uterine cancer and melanoma compared with the other cancer types. Deactivation of IL22RA1 induced a lot of changes in gene expression. IL22RA1 mutants had upregulated DNA damage/repair genes in uterine cancer, whereas downregulated genes in the FoxO signaling pathway. In melanoma, mutation of IL22RA1 can upregulate the HIF signaling pathway but downregulate metabolic pathways. Our study suggests that IL22RA1/JAK/STAT signaling can be an important target for cancer treatment. Frontiers Media S.A. 2022-07-08 /pmc/articles/PMC9304570/ /pubmed/35874683 http://dx.doi.org/10.3389/fimmu.2022.915246 Text en Copyright © 2022 Zhang and Yang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Shuai
Yang, Guiyan
IL22RA1/JAK/STAT Signaling Acts As a Cancer Target Through Pan-Cancer Analysis
title IL22RA1/JAK/STAT Signaling Acts As a Cancer Target Through Pan-Cancer Analysis
title_full IL22RA1/JAK/STAT Signaling Acts As a Cancer Target Through Pan-Cancer Analysis
title_fullStr IL22RA1/JAK/STAT Signaling Acts As a Cancer Target Through Pan-Cancer Analysis
title_full_unstemmed IL22RA1/JAK/STAT Signaling Acts As a Cancer Target Through Pan-Cancer Analysis
title_short IL22RA1/JAK/STAT Signaling Acts As a Cancer Target Through Pan-Cancer Analysis
title_sort il22ra1/jak/stat signaling acts as a cancer target through pan-cancer analysis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304570/
https://www.ncbi.nlm.nih.gov/pubmed/35874683
http://dx.doi.org/10.3389/fimmu.2022.915246
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