The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target

It is acknowledged that chronic inflammation is associated with a rise in extracellular proton concentrations. The acid-sensing ion channel 1a (ASIC1a) belongs to the extracellular H(+)-activated cation channel family. Recently, many studies have been conducted on ASIC1a and inflammatory immune dise...

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Detalles Bibliográficos
Autores principales: Wang, Yinghong, Hu, Xiaojie, Sun, Yancai, Huang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304623/
https://www.ncbi.nlm.nih.gov/pubmed/35873582
http://dx.doi.org/10.3389/fphar.2022.942209
Descripción
Sumario:It is acknowledged that chronic inflammation is associated with a rise in extracellular proton concentrations. The acid-sensing ion channel 1a (ASIC1a) belongs to the extracellular H(+)-activated cation channel family. Recently, many studies have been conducted on ASIC1a and inflammatory immune diseases. Here, in this review, we will focus on the role of ASIC1a in several inflammatory immune diseases so as to provide new perspectives for clinical treatment.

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