The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target

It is acknowledged that chronic inflammation is associated with a rise in extracellular proton concentrations. The acid-sensing ion channel 1a (ASIC1a) belongs to the extracellular H(+)-activated cation channel family. Recently, many studies have been conducted on ASIC1a and inflammatory immune dise...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yinghong, Hu, Xiaojie, Sun, Yancai, Huang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304623/
https://www.ncbi.nlm.nih.gov/pubmed/35873582
http://dx.doi.org/10.3389/fphar.2022.942209
_version_ 1784752129663041536
author Wang, Yinghong
Hu, Xiaojie
Sun, Yancai
Huang, Yan
author_facet Wang, Yinghong
Hu, Xiaojie
Sun, Yancai
Huang, Yan
author_sort Wang, Yinghong
collection PubMed
description It is acknowledged that chronic inflammation is associated with a rise in extracellular proton concentrations. The acid-sensing ion channel 1a (ASIC1a) belongs to the extracellular H(+)-activated cation channel family. Recently, many studies have been conducted on ASIC1a and inflammatory immune diseases. Here, in this review, we will focus on the role of ASIC1a in several inflammatory immune diseases so as to provide new perspectives for clinical treatment.
format Online
Article
Text
id pubmed-9304623
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93046232022-07-23 The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target Wang, Yinghong Hu, Xiaojie Sun, Yancai Huang, Yan Front Pharmacol Pharmacology It is acknowledged that chronic inflammation is associated with a rise in extracellular proton concentrations. The acid-sensing ion channel 1a (ASIC1a) belongs to the extracellular H(+)-activated cation channel family. Recently, many studies have been conducted on ASIC1a and inflammatory immune diseases. Here, in this review, we will focus on the role of ASIC1a in several inflammatory immune diseases so as to provide new perspectives for clinical treatment. Frontiers Media S.A. 2022-07-08 /pmc/articles/PMC9304623/ /pubmed/35873582 http://dx.doi.org/10.3389/fphar.2022.942209 Text en Copyright © 2022 Wang, Hu, Sun and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Wang, Yinghong
Hu, Xiaojie
Sun, Yancai
Huang, Yan
The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target
title The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target
title_full The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target
title_fullStr The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target
title_full_unstemmed The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target
title_short The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target
title_sort role of asic1a in inflammatory immune diseases: a potential therapeutic target
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304623/
https://www.ncbi.nlm.nih.gov/pubmed/35873582
http://dx.doi.org/10.3389/fphar.2022.942209
work_keys_str_mv AT wangyinghong theroleofasic1aininflammatoryimmunediseasesapotentialtherapeutictarget
AT huxiaojie theroleofasic1aininflammatoryimmunediseasesapotentialtherapeutictarget
AT sunyancai theroleofasic1aininflammatoryimmunediseasesapotentialtherapeutictarget
AT huangyan theroleofasic1aininflammatoryimmunediseasesapotentialtherapeutictarget
AT wangyinghong roleofasic1aininflammatoryimmunediseasesapotentialtherapeutictarget
AT huxiaojie roleofasic1aininflammatoryimmunediseasesapotentialtherapeutictarget
AT sunyancai roleofasic1aininflammatoryimmunediseasesapotentialtherapeutictarget
AT huangyan roleofasic1aininflammatoryimmunediseasesapotentialtherapeutictarget

Ejemplares similares