Incorporation of fucose into glycans independent of the GDP-fucose transporter SLC35C1 preferentially utilizes salvaged over de novo GDP-fucose

Mutations in the SLC35C1 gene encoding the Golgi GDP-fucose transporter are known to cause leukocyte adhesion deficiency II. However, improvement of fucosylation in leukocyte adhesion deficiency II patients treated with exogenous fucose suggests the existence of an SLC35C1-independent route of GDP-f...

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Detalles Bibliográficos
Autores principales: Skurska, Edyta, Szulc, Bożena, Maszczak-Seneczko, Dorota, Wiktor, Maciej, Wiertelak, Wojciech, Makowiecka, Aleksandra, Olczak, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304781/
https://www.ncbi.nlm.nih.gov/pubmed/35772493
http://dx.doi.org/10.1016/j.jbc.2022.102206

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