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Subcellular dynamics and functional activity of the cleaved intracellular domain of the Na(+) channel β1 subunit

The voltage-gated Na(+) channel β1 subunit, encoded by SCN1B, regulates cell surface expression and gating of α subunits and participates in cell adhesion. β1 is cleaved by α/β and γ-secretases, releasing an extracellular domain and intracellular domain (ICD), respectively. Abnormal SCN1B expression...

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Detalles Bibliográficos
Autores principales:	Haworth, Alexander S., Hodges, Samantha L., Capatina, Alina L., Isom, Lori L., Baumann, Christoph G., Brackenbury, William J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304784/ https://www.ncbi.nlm.nih.gov/pubmed/35752364 http://dx.doi.org/10.1016/j.jbc.2022.102174

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