Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice

Major depressive disorder (MDD) is a severe disease of unknown pathogenesis that will affect ∼10% of people during their lifetime. Therapy for MDD requires prolonged treatment and often fails, predicating a need for novel treatment strategies. Here, we report increased ceramide levels in the blood p...

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Detalles Bibliográficos
Autores principales: Schumacher, Fabian, Edwards, Michael J., Mühle, Christiane, Carpinteiro, Alexander, Wilson, Greg C., Wilker, Barbara, Soddemann, Matthias, Keitsch, Simone, Scherbaum, Norbert, Müller, Bernhard W., Lang, Undine E., Linnemann, Christoph, Kleuser, Burkhard, Müller, Christian P., Kornhuber, Johannes, Gulbins, Erich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304786/
https://www.ncbi.nlm.nih.gov/pubmed/35753355
http://dx.doi.org/10.1016/j.jbc.2022.102185

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