Genome-wide CRISPR screen identified a role for commander complex mediated ITGB1 recycling in basal insulin secretion

OBJECTIVES: Pancreatic beta cells secrete insulin postprandially and during fasting to maintain glucose homeostasis. Although glucose-stimulated insulin secretion (GSIS) has been extensively studied, much less is known about basal insulin secretion. Here, we performed a genome-wide CRISPR/Cas9 knock...

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Detalles Bibliográficos
Autores principales: Yang, Liu, Fye, Margret A., Yang, Bingyuan, Tang, Zihan, Zhang, Yue, Haigh, Sander, Covington, Brittney A., Bracey, Kai, Taraska, Justin W., Kaverina, Irina, Qu, Shen, Chen, Wenbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304790/
https://www.ncbi.nlm.nih.gov/pubmed/35835371
http://dx.doi.org/10.1016/j.molmet.2022.101541

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