Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity

Lysosome membranes contain diverse phosphoinositide (PtdIns) lipids that coordinate lysosome function and dynamics. The PtdIns repertoire on lysosomes is tightly regulated by the actions of diverse PtdIns kinases and phosphatases; however, specific roles for PtdIns in lysosomal functions and dynamic...

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Detalles Bibliográficos
Autores principales: Saffi, Golam T., Wang, Cheng An, Mangialardi, Emily M., Vacher, Jean, Botelho, Roberto J., Salmena, Leonardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304791/
https://www.ncbi.nlm.nih.gov/pubmed/35760104
http://dx.doi.org/10.1016/j.jbc.2022.102187

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