Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies

Despite decades of research and successful improvements in diagnosis and therapy, prostate cancer (PC) remains a major challenge. In recent years, it has become clear that PC stem cells (PCSCs) are the driving force in tumorigenesis, relapse, metastasis, and therapeutic resistance of PC. In this min...

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Detalles Bibliográficos
Autores principales: Wolf, Isis, Gratzke, Christian, Wolf, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304860/
https://www.ncbi.nlm.nih.gov/pubmed/35875084
http://dx.doi.org/10.3389/fonc.2022.935715
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author Wolf, Isis
Gratzke, Christian
Wolf, Philipp
author_facet Wolf, Isis
Gratzke, Christian
Wolf, Philipp
author_sort Wolf, Isis
collection PubMed
description Despite decades of research and successful improvements in diagnosis and therapy, prostate cancer (PC) remains a major challenge. In recent years, it has become clear that PC stem cells (PCSCs) are the driving force in tumorigenesis, relapse, metastasis, and therapeutic resistance of PC. In this minireview, we discuss the impact of PCSCs in the clinical practice. Moreover, new therapeutic approaches to combat PCSCs are presented with the aim to achieve an improved outcome for patients with PC.
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spelling pubmed-93048602022-07-23 Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies Wolf, Isis Gratzke, Christian Wolf, Philipp Front Oncol Oncology Despite decades of research and successful improvements in diagnosis and therapy, prostate cancer (PC) remains a major challenge. In recent years, it has become clear that PC stem cells (PCSCs) are the driving force in tumorigenesis, relapse, metastasis, and therapeutic resistance of PC. In this minireview, we discuss the impact of PCSCs in the clinical practice. Moreover, new therapeutic approaches to combat PCSCs are presented with the aim to achieve an improved outcome for patients with PC. Frontiers Media S.A. 2022-07-08 /pmc/articles/PMC9304860/ /pubmed/35875084 http://dx.doi.org/10.3389/fonc.2022.935715 Text en Copyright © 2022 Wolf, Gratzke and Wolf https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wolf, Isis
Gratzke, Christian
Wolf, Philipp
Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies
title Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies
title_full Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies
title_fullStr Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies
title_full_unstemmed Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies
title_short Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies
title_sort prostate cancer stem cells: clinical aspects and targeted therapies
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304860/
https://www.ncbi.nlm.nih.gov/pubmed/35875084
http://dx.doi.org/10.3389/fonc.2022.935715
work_keys_str_mv AT wolfisis prostatecancerstemcellsclinicalaspectsandtargetedtherapies
AT gratzkechristian prostatecancerstemcellsclinicalaspectsandtargetedtherapies
AT wolfphilipp prostatecancerstemcellsclinicalaspectsandtargetedtherapies

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