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Clinical Impact of the Histopathological Index and Neuroimaging Features Status in Primary Central Nervous System Diffuse Large B-Cell Lymphoma: A Single-Center Retrospective Analysis of 51 Cases

Primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL) is an uncommon non-Hodgkin lymphoma subtype, and its clinical and pathological characteristics remain unclear. PCNS-DLBCL patient data were retrospectively evaluated to determine clinical and pathological characteristics and p...

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Autores principales: Qi, Zhou, Duan, Lei, Yuan, Guoqiang, Liu, Jianli, Li, Jian, Li, Guoqiang, Yu, Yue, Xu, Yanlong, Ma, Shangxian, Pan, Yawen, Zhang, Yinian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304881/
https://www.ncbi.nlm.nih.gov/pubmed/35875161
http://dx.doi.org/10.3389/fonc.2022.769895
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author Qi, Zhou
Duan, Lei
Yuan, Guoqiang
Liu, Jianli
Li, Jian
Li, Guoqiang
Yu, Yue
Xu, Yanlong
Ma, Shangxian
Pan, Yawen
Zhang, Yinian
author_facet Qi, Zhou
Duan, Lei
Yuan, Guoqiang
Liu, Jianli
Li, Jian
Li, Guoqiang
Yu, Yue
Xu, Yanlong
Ma, Shangxian
Pan, Yawen
Zhang, Yinian
author_sort Qi, Zhou
collection PubMed
description Primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL) is an uncommon non-Hodgkin lymphoma subtype, and its clinical and pathological characteristics remain unclear. PCNS-DLBCL patient data were retrospectively evaluated to determine clinical and pathological characteristics and prognostic factors. Furthermore, prognoses were calculated by Kaplan–Meier and Cox regression models based on clinical observations. In total, 51 immunocompetent patients were enrolled. The median age was 55 (range, 16–82) years, and the male-to-female ratio was 3:2. Headache (n = 19; 37%) and the frontal lobe (n = 16; 31%) were the most common presenting symptom and location, respectively. The median follow-up was 33 (range, 3–86) months, and the median overall survival (OS) and progression-free survival (PFS) were 18 months [95% confidence interval (CI), 21.2–34.2] and 15 months (95% CI, 16.9–28.7), respectively. Ki-67, cluster of differentiation-3, and deep brain involvement were independent prognostic markers. Moreover, multifocal lesions and deep brain involvement were unfavorable independent prognostic markers for PFS. This study indicates that targeted drug development for adverse prognostic factors is possible and provides guidance for clinical treatment decision-making.
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spelling pubmed-93048812022-07-23 Clinical Impact of the Histopathological Index and Neuroimaging Features Status in Primary Central Nervous System Diffuse Large B-Cell Lymphoma: A Single-Center Retrospective Analysis of 51 Cases Qi, Zhou Duan, Lei Yuan, Guoqiang Liu, Jianli Li, Jian Li, Guoqiang Yu, Yue Xu, Yanlong Ma, Shangxian Pan, Yawen Zhang, Yinian Front Oncol Oncology Primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL) is an uncommon non-Hodgkin lymphoma subtype, and its clinical and pathological characteristics remain unclear. PCNS-DLBCL patient data were retrospectively evaluated to determine clinical and pathological characteristics and prognostic factors. Furthermore, prognoses were calculated by Kaplan–Meier and Cox regression models based on clinical observations. In total, 51 immunocompetent patients were enrolled. The median age was 55 (range, 16–82) years, and the male-to-female ratio was 3:2. Headache (n = 19; 37%) and the frontal lobe (n = 16; 31%) were the most common presenting symptom and location, respectively. The median follow-up was 33 (range, 3–86) months, and the median overall survival (OS) and progression-free survival (PFS) were 18 months [95% confidence interval (CI), 21.2–34.2] and 15 months (95% CI, 16.9–28.7), respectively. Ki-67, cluster of differentiation-3, and deep brain involvement were independent prognostic markers. Moreover, multifocal lesions and deep brain involvement were unfavorable independent prognostic markers for PFS. This study indicates that targeted drug development for adverse prognostic factors is possible and provides guidance for clinical treatment decision-making. Frontiers Media S.A. 2022-07-08 /pmc/articles/PMC9304881/ /pubmed/35875161 http://dx.doi.org/10.3389/fonc.2022.769895 Text en Copyright © 2022 Qi, Duan, Yuan, Liu, Li, Li, Yu, Xu, Ma, Pan and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Qi, Zhou
Duan, Lei
Yuan, Guoqiang
Liu, Jianli
Li, Jian
Li, Guoqiang
Yu, Yue
Xu, Yanlong
Ma, Shangxian
Pan, Yawen
Zhang, Yinian
Clinical Impact of the Histopathological Index and Neuroimaging Features Status in Primary Central Nervous System Diffuse Large B-Cell Lymphoma: A Single-Center Retrospective Analysis of 51 Cases
title Clinical Impact of the Histopathological Index and Neuroimaging Features Status in Primary Central Nervous System Diffuse Large B-Cell Lymphoma: A Single-Center Retrospective Analysis of 51 Cases
title_full Clinical Impact of the Histopathological Index and Neuroimaging Features Status in Primary Central Nervous System Diffuse Large B-Cell Lymphoma: A Single-Center Retrospective Analysis of 51 Cases
title_fullStr Clinical Impact of the Histopathological Index and Neuroimaging Features Status in Primary Central Nervous System Diffuse Large B-Cell Lymphoma: A Single-Center Retrospective Analysis of 51 Cases
title_full_unstemmed Clinical Impact of the Histopathological Index and Neuroimaging Features Status in Primary Central Nervous System Diffuse Large B-Cell Lymphoma: A Single-Center Retrospective Analysis of 51 Cases
title_short Clinical Impact of the Histopathological Index and Neuroimaging Features Status in Primary Central Nervous System Diffuse Large B-Cell Lymphoma: A Single-Center Retrospective Analysis of 51 Cases
title_sort clinical impact of the histopathological index and neuroimaging features status in primary central nervous system diffuse large b-cell lymphoma: a single-center retrospective analysis of 51 cases
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304881/
https://www.ncbi.nlm.nih.gov/pubmed/35875161
http://dx.doi.org/10.3389/fonc.2022.769895
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