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Construction of BHV-1 UL41 Defective Virus Using the CRISPR/Cas9 System and Analysis of Viral Replication Properties

Bovine herpesvirus type 1 (BHV-1) is a neurotropic herpesvirus that causes infectious rhinotracheitis and vulvovaginitis in cattle. The virion host shutoff protein encoded by the BHV-1 UL41 gene is highly conserved in the Alphaherpesvirinae subfamily. This protein can degrade viral and host messenge...

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Detalles Bibliográficos
Autores principales:	Dai, Haiyue, Wu, Jianan, Yang, Hongshu, Guo, Yongli, Di, Haoqing, Gao, Mingchun, Wang, Junwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304932/ https://www.ncbi.nlm.nih.gov/pubmed/35873151 http://dx.doi.org/10.3389/fcimb.2022.942987

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