Cargando…
Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19
Whereas the detection of antiphospholipid autoantibodies (aPL) in COVID-19 is of increasing interest, their role is still unclear. We analyzed a large aPL panel in 157 patients with COVID-19 according to the disease severity. We also investigated a potential association between aPL and extracellular...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305055/ https://www.ncbi.nlm.nih.gov/pubmed/35869087 http://dx.doi.org/10.1038/s41598-022-15969-y |
_version_ | 1784752231088652288 |
---|---|
author | Bertin, Daniel Brodovitch, Alexandre Lopez, Alexandre Arcani, Robin Thomas, Grace M. Beziane, Abdou Weber, Samuel Babacci, Benjamin Heim, Xavier Rey, Louise Leone, Marc Mege, Jean Louis Bardin, Nathalie |
author_facet | Bertin, Daniel Brodovitch, Alexandre Lopez, Alexandre Arcani, Robin Thomas, Grace M. Beziane, Abdou Weber, Samuel Babacci, Benjamin Heim, Xavier Rey, Louise Leone, Marc Mege, Jean Louis Bardin, Nathalie |
author_sort | Bertin, Daniel |
collection | PubMed |
description | Whereas the detection of antiphospholipid autoantibodies (aPL) in COVID-19 is of increasing interest, their role is still unclear. We analyzed a large aPL panel in 157 patients with COVID-19 according to the disease severity. We also investigated a potential association between aPL and extracellular DNA (exDNA, n = 85) or circulating markers of neutrophil extracellular traps (NET) such as citrullinated histones H3 (CitH3, n = 49). A total of 157 sera of patients infected by SARS-CoV-2 were collected. A large aPL panel including lupus anticoagulant, anti-cardiolipin and anti-beta-2 glycoprotein I (IgG, IgM and IgA), anti-phosphatidylethanolamine IgA, anti-prothrombin (IgG and IgM) was retrospectively analyzed according to the disease severity. We found a total aPL prevalence of 54.8% with almost half of the cases having aCL IgG. Within an extended panel of aPL, only aCL IgG were associated with COVID-19 severity. Additionally, severe patients displayed higher CitH3 levels than mild patients. Interestingly, we highlighted a significant association between the levels of aCL IgG and exDNA only in aCL positive patients with severe disease. In conclusion, we showed a significant link between aPL, namely aCL IgG, and circulating exDNA in patients with severe form of COVID-19, that could exacerbate the thrombo-inflammatory state related to disease severity. |
format | Online Article Text |
id | pubmed-9305055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-93050552022-07-22 Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19 Bertin, Daniel Brodovitch, Alexandre Lopez, Alexandre Arcani, Robin Thomas, Grace M. Beziane, Abdou Weber, Samuel Babacci, Benjamin Heim, Xavier Rey, Louise Leone, Marc Mege, Jean Louis Bardin, Nathalie Sci Rep Article Whereas the detection of antiphospholipid autoantibodies (aPL) in COVID-19 is of increasing interest, their role is still unclear. We analyzed a large aPL panel in 157 patients with COVID-19 according to the disease severity. We also investigated a potential association between aPL and extracellular DNA (exDNA, n = 85) or circulating markers of neutrophil extracellular traps (NET) such as citrullinated histones H3 (CitH3, n = 49). A total of 157 sera of patients infected by SARS-CoV-2 were collected. A large aPL panel including lupus anticoagulant, anti-cardiolipin and anti-beta-2 glycoprotein I (IgG, IgM and IgA), anti-phosphatidylethanolamine IgA, anti-prothrombin (IgG and IgM) was retrospectively analyzed according to the disease severity. We found a total aPL prevalence of 54.8% with almost half of the cases having aCL IgG. Within an extended panel of aPL, only aCL IgG were associated with COVID-19 severity. Additionally, severe patients displayed higher CitH3 levels than mild patients. Interestingly, we highlighted a significant association between the levels of aCL IgG and exDNA only in aCL positive patients with severe disease. In conclusion, we showed a significant link between aPL, namely aCL IgG, and circulating exDNA in patients with severe form of COVID-19, that could exacerbate the thrombo-inflammatory state related to disease severity. Nature Publishing Group UK 2022-07-22 /pmc/articles/PMC9305055/ /pubmed/35869087 http://dx.doi.org/10.1038/s41598-022-15969-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Bertin, Daniel Brodovitch, Alexandre Lopez, Alexandre Arcani, Robin Thomas, Grace M. Beziane, Abdou Weber, Samuel Babacci, Benjamin Heim, Xavier Rey, Louise Leone, Marc Mege, Jean Louis Bardin, Nathalie Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19 |
title | Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19 |
title_full | Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19 |
title_fullStr | Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19 |
title_full_unstemmed | Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19 |
title_short | Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19 |
title_sort | anti-cardiolipin igg autoantibodies associate with circulating extracellular dna in severe covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305055/ https://www.ncbi.nlm.nih.gov/pubmed/35869087 http://dx.doi.org/10.1038/s41598-022-15969-y |
work_keys_str_mv | AT bertindaniel anticardiolipiniggautoantibodiesassociatewithcirculatingextracellulardnainseverecovid19 AT brodovitchalexandre anticardiolipiniggautoantibodiesassociatewithcirculatingextracellulardnainseverecovid19 AT lopezalexandre anticardiolipiniggautoantibodiesassociatewithcirculatingextracellulardnainseverecovid19 AT arcanirobin anticardiolipiniggautoantibodiesassociatewithcirculatingextracellulardnainseverecovid19 AT thomasgracem anticardiolipiniggautoantibodiesassociatewithcirculatingextracellulardnainseverecovid19 AT bezianeabdou anticardiolipiniggautoantibodiesassociatewithcirculatingextracellulardnainseverecovid19 AT webersamuel anticardiolipiniggautoantibodiesassociatewithcirculatingextracellulardnainseverecovid19 AT babaccibenjamin anticardiolipiniggautoantibodiesassociatewithcirculatingextracellulardnainseverecovid19 AT heimxavier anticardiolipiniggautoantibodiesassociatewithcirculatingextracellulardnainseverecovid19 AT reylouise anticardiolipiniggautoantibodiesassociatewithcirculatingextracellulardnainseverecovid19 AT leonemarc anticardiolipiniggautoantibodiesassociatewithcirculatingextracellulardnainseverecovid19 AT megejeanlouis anticardiolipiniggautoantibodiesassociatewithcirculatingextracellulardnainseverecovid19 AT bardinnathalie anticardiolipiniggautoantibodiesassociatewithcirculatingextracellulardnainseverecovid19 |