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Serum Calprotectin Level Is Independently Associated With Carotid Plaque Presence in Patients With Psoriatic Arthritis

BACKGROUND: Whether calprotectin could play a role in augmenting cardiovascular (CV) risk in patients with psoriatic arthritis (PsA) remains uncertain. The aim of this study is to elucidate the association between serum calprotectin level and subclinical atherosclerosis in patient with PsA. METHOD:...

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Autores principales: Cheng, Isaac T., Meng, Huan, Li, Martin, Li, Edmund K., Wong, Priscilla C., Lee, Jack, Yan, Bryan P., Lee, Alex P. W., So, Ho, Tam, Lai-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305068/
https://www.ncbi.nlm.nih.gov/pubmed/35872782
http://dx.doi.org/10.3389/fmed.2022.932696
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author Cheng, Isaac T.
Meng, Huan
Li, Martin
Li, Edmund K.
Wong, Priscilla C.
Lee, Jack
Yan, Bryan P.
Lee, Alex P. W.
So, Ho
Tam, Lai-Shan
author_facet Cheng, Isaac T.
Meng, Huan
Li, Martin
Li, Edmund K.
Wong, Priscilla C.
Lee, Jack
Yan, Bryan P.
Lee, Alex P. W.
So, Ho
Tam, Lai-Shan
author_sort Cheng, Isaac T.
collection PubMed
description BACKGROUND: Whether calprotectin could play a role in augmenting cardiovascular (CV) risk in patients with psoriatic arthritis (PsA) remains uncertain. The aim of this study is to elucidate the association between serum calprotectin level and subclinical atherosclerosis in patient with PsA. METHOD: Seventy-eight PsA patients (age: 52 ± 10 years, 41 [52.6%] male) without CV disease were recruited into this cross-sectional study. Carotid intima-media thickness (cIMT) and the presence of plaque were determined by high-resolution ultrasound. Calprotectin levels in serum were quantified by enzyme-linked immunosorbent assay. The variables associated with the presence of carotid plaque (CP) were selected from the least absolute shrinkage and selection operator (LASSO) regression analysis. RESULTS: 29/78 (37.2%) of patient had carotid plaque (CP+ group). Serum calprotectin level was significantly higher in the CP+ group (CP− group: 564.6 [329.3–910.5] ng/ml; CP+ group: 721.3 [329.3–910.5] ng/ml, P = 0.005). Serum calprotectin level correlated with PsA disease duration (rho = 0.280, P = 0.013) and mean cIMT (rho = 0.249, P = 0.038). Using LASSO regression analysis, the levels of Ln-calprotectin (OR: 3.38, 95% CI [1.37, 9.47]; P = 0.026) and PsA disease duration (OR: 1.09, 95% CI [1.01, 1.18]; P = 0.013) were screened out from a total of 19 variables. The model in predicting the presence of CP was constructed by Ln-calprotectin and PsA disease duration with an area under the receiver-operating characteristic (ROC) curve of 0.744, (95 CI% [0.59, 0.80], P = 0.037). CONCLUSION: Serum calprotectin level is associated with the presence of CP in PsA. Further studies are required to confirm whether this pathway is associated with CV events in PsA.
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spelling pubmed-93050682022-07-23 Serum Calprotectin Level Is Independently Associated With Carotid Plaque Presence in Patients With Psoriatic Arthritis Cheng, Isaac T. Meng, Huan Li, Martin Li, Edmund K. Wong, Priscilla C. Lee, Jack Yan, Bryan P. Lee, Alex P. W. So, Ho Tam, Lai-Shan Front Med (Lausanne) Medicine BACKGROUND: Whether calprotectin could play a role in augmenting cardiovascular (CV) risk in patients with psoriatic arthritis (PsA) remains uncertain. The aim of this study is to elucidate the association between serum calprotectin level and subclinical atherosclerosis in patient with PsA. METHOD: Seventy-eight PsA patients (age: 52 ± 10 years, 41 [52.6%] male) without CV disease were recruited into this cross-sectional study. Carotid intima-media thickness (cIMT) and the presence of plaque were determined by high-resolution ultrasound. Calprotectin levels in serum were quantified by enzyme-linked immunosorbent assay. The variables associated with the presence of carotid plaque (CP) were selected from the least absolute shrinkage and selection operator (LASSO) regression analysis. RESULTS: 29/78 (37.2%) of patient had carotid plaque (CP+ group). Serum calprotectin level was significantly higher in the CP+ group (CP− group: 564.6 [329.3–910.5] ng/ml; CP+ group: 721.3 [329.3–910.5] ng/ml, P = 0.005). Serum calprotectin level correlated with PsA disease duration (rho = 0.280, P = 0.013) and mean cIMT (rho = 0.249, P = 0.038). Using LASSO regression analysis, the levels of Ln-calprotectin (OR: 3.38, 95% CI [1.37, 9.47]; P = 0.026) and PsA disease duration (OR: 1.09, 95% CI [1.01, 1.18]; P = 0.013) were screened out from a total of 19 variables. The model in predicting the presence of CP was constructed by Ln-calprotectin and PsA disease duration with an area under the receiver-operating characteristic (ROC) curve of 0.744, (95 CI% [0.59, 0.80], P = 0.037). CONCLUSION: Serum calprotectin level is associated with the presence of CP in PsA. Further studies are required to confirm whether this pathway is associated with CV events in PsA. Frontiers Media S.A. 2022-07-08 /pmc/articles/PMC9305068/ /pubmed/35872782 http://dx.doi.org/10.3389/fmed.2022.932696 Text en Copyright © 2022 Cheng, Meng, Li, Li, Wong, Lee, Yan, Lee, So and Tam. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Cheng, Isaac T.
Meng, Huan
Li, Martin
Li, Edmund K.
Wong, Priscilla C.
Lee, Jack
Yan, Bryan P.
Lee, Alex P. W.
So, Ho
Tam, Lai-Shan
Serum Calprotectin Level Is Independently Associated With Carotid Plaque Presence in Patients With Psoriatic Arthritis
title Serum Calprotectin Level Is Independently Associated With Carotid Plaque Presence in Patients With Psoriatic Arthritis
title_full Serum Calprotectin Level Is Independently Associated With Carotid Plaque Presence in Patients With Psoriatic Arthritis
title_fullStr Serum Calprotectin Level Is Independently Associated With Carotid Plaque Presence in Patients With Psoriatic Arthritis
title_full_unstemmed Serum Calprotectin Level Is Independently Associated With Carotid Plaque Presence in Patients With Psoriatic Arthritis
title_short Serum Calprotectin Level Is Independently Associated With Carotid Plaque Presence in Patients With Psoriatic Arthritis
title_sort serum calprotectin level is independently associated with carotid plaque presence in patients with psoriatic arthritis
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305068/
https://www.ncbi.nlm.nih.gov/pubmed/35872782
http://dx.doi.org/10.3389/fmed.2022.932696
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