Performance of Machine Learning for Tissue Outcome Prediction in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

Machine learning (ML) has been proposed for lesion segmentation in acute ischemic stroke (AIS). This study aimed to provide a systematic review and meta-analysis of the overall performance of current ML algorithms for final infarct prediction from baseline imaging. We made a comprehensive literature search on eligible studies developing ML models for core infarcted tissue estimation on admission CT or MRI in AIS patients. Eleven studies meeting the inclusion criteria were included in the quantitative analysis. Study characteristics, model methodology, and predictive performance of the included studies were extracted. A meta-analysis was conducted on the dice similarity coefficient (DSC) score by using a random-effects model to assess the overall predictive performance. Study heterogeneity was assessed by Cochrane Q and Higgins I(2) tests. The pooled DSC score of the included ML models was 0.50 (95% CI 0.39–0.61), with high heterogeneity observed across studies (I(2) 96.5%, p < 0.001). Sensitivity analyses using the one-study removed method showed the adjusted overall DSC score ranged from 0.47 to 0.52. Subgroup analyses indicated that the DL-based models outperformed the conventional ML classifiers with the best performance observed in DL algorithms combined with CT data. Despite the presence of heterogeneity, current ML-based approaches for final infarct prediction showed moderate but promising performance. Before well integrated into clinical stroke workflow, future investigations are suggested to train ML models on large-scale, multi-vendor data, validate on external cohorts and adopt formalized reporting standards for improving model accuracy and robustness.