Cargando…
Mitochondrial-Dependent and Independent Functions of PINK1
PINK1 has been characterized as a mitochondrial kinase that can target to damaged mitochondria to initiate mitophagy, a process to remove unhealthy mitochondria for protecting neuronal cells. Mutations of the human PINK1 gene are also found to cause early onset Parkinson’s disease, a neurodegenerati...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305176/ https://www.ncbi.nlm.nih.gov/pubmed/35874823 http://dx.doi.org/10.3389/fcell.2022.954536 |
_version_ | 1784752262338314240 |
---|---|
author | Chen, Xiusheng Wang, Qi Li, Shihua Li, Xiao-Jiang Yang, Weili |
author_facet | Chen, Xiusheng Wang, Qi Li, Shihua Li, Xiao-Jiang Yang, Weili |
author_sort | Chen, Xiusheng |
collection | PubMed |
description | PINK1 has been characterized as a mitochondrial kinase that can target to damaged mitochondria to initiate mitophagy, a process to remove unhealthy mitochondria for protecting neuronal cells. Mutations of the human PINK1 gene are also found to cause early onset Parkinson’s disease, a neurodegenerative disorder with the pathological feature of mitochondrial dysfunction. Despite compelling evidence from in vitro studies to support the role of PINK1 in regulation of mitochondrial function, there is still lack of strong in vivo evidence to validate PINK1-mediated mitophagy in the brain. In addition, growing evidence indicates that PINK1 also executes function independent of mitochondria. In this review, we discuss the mitochondrial dependent and independent functions of PINK1, aiming at elucidating how PINK1 functions differentially under different circumstances. |
format | Online Article Text |
id | pubmed-9305176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93051762022-07-23 Mitochondrial-Dependent and Independent Functions of PINK1 Chen, Xiusheng Wang, Qi Li, Shihua Li, Xiao-Jiang Yang, Weili Front Cell Dev Biol Cell and Developmental Biology PINK1 has been characterized as a mitochondrial kinase that can target to damaged mitochondria to initiate mitophagy, a process to remove unhealthy mitochondria for protecting neuronal cells. Mutations of the human PINK1 gene are also found to cause early onset Parkinson’s disease, a neurodegenerative disorder with the pathological feature of mitochondrial dysfunction. Despite compelling evidence from in vitro studies to support the role of PINK1 in regulation of mitochondrial function, there is still lack of strong in vivo evidence to validate PINK1-mediated mitophagy in the brain. In addition, growing evidence indicates that PINK1 also executes function independent of mitochondria. In this review, we discuss the mitochondrial dependent and independent functions of PINK1, aiming at elucidating how PINK1 functions differentially under different circumstances. Frontiers Media S.A. 2022-07-08 /pmc/articles/PMC9305176/ /pubmed/35874823 http://dx.doi.org/10.3389/fcell.2022.954536 Text en Copyright © 2022 Chen, Wang, Li, Li and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Chen, Xiusheng Wang, Qi Li, Shihua Li, Xiao-Jiang Yang, Weili Mitochondrial-Dependent and Independent Functions of PINK1 |
title | Mitochondrial-Dependent and Independent Functions of PINK1 |
title_full | Mitochondrial-Dependent and Independent Functions of PINK1 |
title_fullStr | Mitochondrial-Dependent and Independent Functions of PINK1 |
title_full_unstemmed | Mitochondrial-Dependent and Independent Functions of PINK1 |
title_short | Mitochondrial-Dependent and Independent Functions of PINK1 |
title_sort | mitochondrial-dependent and independent functions of pink1 |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305176/ https://www.ncbi.nlm.nih.gov/pubmed/35874823 http://dx.doi.org/10.3389/fcell.2022.954536 |
work_keys_str_mv | AT chenxiusheng mitochondrialdependentandindependentfunctionsofpink1 AT wangqi mitochondrialdependentandindependentfunctionsofpink1 AT lishihua mitochondrialdependentandindependentfunctionsofpink1 AT lixiaojiang mitochondrialdependentandindependentfunctionsofpink1 AT yangweili mitochondrialdependentandindependentfunctionsofpink1 |