Cargando…

Mitochondrial-Dependent and Independent Functions of PINK1

PINK1 has been characterized as a mitochondrial kinase that can target to damaged mitochondria to initiate mitophagy, a process to remove unhealthy mitochondria for protecting neuronal cells. Mutations of the human PINK1 gene are also found to cause early onset Parkinson’s disease, a neurodegenerati...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Xiusheng, Wang, Qi, Li, Shihua, Li, Xiao-Jiang, Yang, Weili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305176/
https://www.ncbi.nlm.nih.gov/pubmed/35874823
http://dx.doi.org/10.3389/fcell.2022.954536
_version_ 1784752262338314240
author Chen, Xiusheng
Wang, Qi
Li, Shihua
Li, Xiao-Jiang
Yang, Weili
author_facet Chen, Xiusheng
Wang, Qi
Li, Shihua
Li, Xiao-Jiang
Yang, Weili
author_sort Chen, Xiusheng
collection PubMed
description PINK1 has been characterized as a mitochondrial kinase that can target to damaged mitochondria to initiate mitophagy, a process to remove unhealthy mitochondria for protecting neuronal cells. Mutations of the human PINK1 gene are also found to cause early onset Parkinson’s disease, a neurodegenerative disorder with the pathological feature of mitochondrial dysfunction. Despite compelling evidence from in vitro studies to support the role of PINK1 in regulation of mitochondrial function, there is still lack of strong in vivo evidence to validate PINK1-mediated mitophagy in the brain. In addition, growing evidence indicates that PINK1 also executes function independent of mitochondria. In this review, we discuss the mitochondrial dependent and independent functions of PINK1, aiming at elucidating how PINK1 functions differentially under different circumstances.
format Online
Article
Text
id pubmed-9305176
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93051762022-07-23 Mitochondrial-Dependent and Independent Functions of PINK1 Chen, Xiusheng Wang, Qi Li, Shihua Li, Xiao-Jiang Yang, Weili Front Cell Dev Biol Cell and Developmental Biology PINK1 has been characterized as a mitochondrial kinase that can target to damaged mitochondria to initiate mitophagy, a process to remove unhealthy mitochondria for protecting neuronal cells. Mutations of the human PINK1 gene are also found to cause early onset Parkinson’s disease, a neurodegenerative disorder with the pathological feature of mitochondrial dysfunction. Despite compelling evidence from in vitro studies to support the role of PINK1 in regulation of mitochondrial function, there is still lack of strong in vivo evidence to validate PINK1-mediated mitophagy in the brain. In addition, growing evidence indicates that PINK1 also executes function independent of mitochondria. In this review, we discuss the mitochondrial dependent and independent functions of PINK1, aiming at elucidating how PINK1 functions differentially under different circumstances. Frontiers Media S.A. 2022-07-08 /pmc/articles/PMC9305176/ /pubmed/35874823 http://dx.doi.org/10.3389/fcell.2022.954536 Text en Copyright © 2022 Chen, Wang, Li, Li and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Chen, Xiusheng
Wang, Qi
Li, Shihua
Li, Xiao-Jiang
Yang, Weili
Mitochondrial-Dependent and Independent Functions of PINK1
title Mitochondrial-Dependent and Independent Functions of PINK1
title_full Mitochondrial-Dependent and Independent Functions of PINK1
title_fullStr Mitochondrial-Dependent and Independent Functions of PINK1
title_full_unstemmed Mitochondrial-Dependent and Independent Functions of PINK1
title_short Mitochondrial-Dependent and Independent Functions of PINK1
title_sort mitochondrial-dependent and independent functions of pink1
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305176/
https://www.ncbi.nlm.nih.gov/pubmed/35874823
http://dx.doi.org/10.3389/fcell.2022.954536
work_keys_str_mv AT chenxiusheng mitochondrialdependentandindependentfunctionsofpink1
AT wangqi mitochondrialdependentandindependentfunctionsofpink1
AT lishihua mitochondrialdependentandindependentfunctionsofpink1
AT lixiaojiang mitochondrialdependentandindependentfunctionsofpink1
AT yangweili mitochondrialdependentandindependentfunctionsofpink1