Neurodegeneration and neuroinflammation are linked, but independent of alpha‐synuclein inclusions, in a seeding/spreading mouse model of Parkinson's disease

A key pathological process in Parkinson's disease (PD) is the transneuronal spreading of α‐synuclein. Alpha‐synuclein (α‐syn) is a presynaptic protein that, in PD, forms pathological inclusions. Other hallmarks of PD include neurodegeneration and microgliosis in susceptible brain regions. Wheth...

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Detalles Bibliográficos
Autores principales: Garcia, Pierre, Jürgens‐Wemheuer, Wiebke, Uriarte Huarte, Oihane, Michelucci, Alessandro, Masuch, Annette, Brioschi, Simone, Weihofen, Andreas, Koncina, Eric, Coowar, Djalil, Heurtaux, Tony, Glaab, Enrico, Balling, Rudi, Sousa, Carole, Kaoma, Tony, Nicot, Nathalie, Pfander, Tatjana, Schulz‐Schaeffer, Walter, Allouche, Ahmad, Fischer, Nicolas, Biber, Knut, Kleine‐Borgmann, Felix, Mittelbronn, Michel, Ostaszewski, Marek, Schmit, Kristopher J., Buttini, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305192/
https://www.ncbi.nlm.nih.gov/pubmed/35092321
http://dx.doi.org/10.1002/glia.24149

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