Emapalumab in primary haemophagocytic lymphohistiocytosis and the pathogenic role of interferon gamma: A pharmacometric model‐based approach

AIM: Primary haemophagocytic lymphohistiocytosis (HLH) is a rare, life‐threatening, hyperinflammatory syndrome generally occurring in early childhood. The monoclonal antibody emapalumab binds and neutralises interferon γ (IFNγ). This study aimed to determine an emapalumab dosing regimen when traditi...

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Detalles Bibliográficos
Autores principales: Jacqmin, Philippe, Laveille, Christian, Snoeck, Eric, Jordan, Michael B., Locatelli, Franco, Ballabio, Maria, de Min, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305196/
https://www.ncbi.nlm.nih.gov/pubmed/34935183
http://dx.doi.org/10.1111/bcp.15133

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