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Exploring the enzyme‐catalyzed synthesis of isotope labeled cyclopropanes
Cyclopropanes are commonly employed structural moieties in drug design since their incorporation is often associated with increased target affinity, improved metabolic stability, and increased rigidity to access bioactive conformations. Robust chemical cyclopropanation procedures have been developed...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305206/ https://www.ncbi.nlm.nih.gov/pubmed/34997781 http://dx.doi.org/10.1002/jlcr.3962 |