Phase 2 study for nonmetastatic extremity high‐grade osteosarcoma in pediatric and adolescent and young adult patients with a risk‐adapted strategy based on ABCB1/P‐glycoprotein expression: An Italian Sarcoma Group trial (ISG/OS‐2)

BACKGROUND: According to retrospective osteosarcoma series, ABCB1/P‐glycoprotein (Pgp) overexpression predicts for poor outcomes. A prospective trial to assess a risk‐adapted treatment strategy using mifamurtide in Pgp+ patients was performed. METHODS: This was a phase 2, multicenter, uncontrolled t...

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Detalles Bibliográficos
Autores principales: Palmerini, Emanuela, Meazza, Cristina, Tamburini, Angela, Bisogno, Gianni, Ferraresi, Virginia, Asaftei, Sebastian D., Milano, Giuseppe M., Coccoli, Luca, Manzitti, Carla, Luksch, Roberto, Serra, Massimo, Gambarotti, Marco, Donati, Davide M., Scotlandi, Katia, Bertulli, Rossella, Favre, Claudio, Longhi, Alessandra, Abate, Massimo E., Perrotta, Silverio, Mascarin, Maurizio, D’Angelo, Paolo, Cesari, Marilena, Staals, Eric L., Marchesi, Emanuela, Carretta, Elisa, Ibrahim, Toni, Casali, Paolo G., Picci, Piero, Fagioli, Franca, Ferrari, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305236/
https://www.ncbi.nlm.nih.gov/pubmed/35201621
http://dx.doi.org/10.1002/cncr.34131

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