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The significance of advanced COVID-19 diagnostic testing in pandemic control measures

During the 2 years since the start of the novel coronavirus disease 2019 (COVID-19) pandemic, the scientific world made an enormous effort to fight against this disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has high transmissibility. Advancements in vaccine an...

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Autor principal: Kwok, Hang Fai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305263/
https://www.ncbi.nlm.nih.gov/pubmed/35874951
http://dx.doi.org/10.7150/ijbs.72837
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author Kwok, Hang Fai
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description During the 2 years since the start of the novel coronavirus disease 2019 (COVID-19) pandemic, the scientific world made an enormous effort to fight against this disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has high transmissibility. Advancements in vaccine and treatment strategies have reduced both the hospitalization and mortality rates. However, the virus has shown its ability to evolve and evade from our COVID-19 combating armamentaria by the most common evolution mechanism—mutation. Diagnostic testing has been the first line of defense following the identification of the causative agent. Ever since, the scientific community has developed nuclei acid-based, antigen-based, and antibody-based diagnostic tests, and these testing methodologies are still playing a central role in slowing down viral transmission. These testing methods have different sensitivity and specificity and could be optimally used in areas facing different challenges owing to different level and conditions of COVID-19 outbreak. In this review, we discuss these testing methodologies as well as the considerations on how to apply these diagnostic tests optimally in the community to cope with the ever-changing pandemic conditions.
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spelling pubmed-93052632022-07-22 The significance of advanced COVID-19 diagnostic testing in pandemic control measures Kwok, Hang Fai Int J Biol Sci Review During the 2 years since the start of the novel coronavirus disease 2019 (COVID-19) pandemic, the scientific world made an enormous effort to fight against this disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has high transmissibility. Advancements in vaccine and treatment strategies have reduced both the hospitalization and mortality rates. However, the virus has shown its ability to evolve and evade from our COVID-19 combating armamentaria by the most common evolution mechanism—mutation. Diagnostic testing has been the first line of defense following the identification of the causative agent. Ever since, the scientific community has developed nuclei acid-based, antigen-based, and antibody-based diagnostic tests, and these testing methodologies are still playing a central role in slowing down viral transmission. These testing methods have different sensitivity and specificity and could be optimally used in areas facing different challenges owing to different level and conditions of COVID-19 outbreak. In this review, we discuss these testing methodologies as well as the considerations on how to apply these diagnostic tests optimally in the community to cope with the ever-changing pandemic conditions. Ivyspring International Publisher 2022-07-11 /pmc/articles/PMC9305263/ /pubmed/35874951 http://dx.doi.org/10.7150/ijbs.72837 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Kwok, Hang Fai
The significance of advanced COVID-19 diagnostic testing in pandemic control measures
title The significance of advanced COVID-19 diagnostic testing in pandemic control measures
title_full The significance of advanced COVID-19 diagnostic testing in pandemic control measures
title_fullStr The significance of advanced COVID-19 diagnostic testing in pandemic control measures
title_full_unstemmed The significance of advanced COVID-19 diagnostic testing in pandemic control measures
title_short The significance of advanced COVID-19 diagnostic testing in pandemic control measures
title_sort significance of advanced covid-19 diagnostic testing in pandemic control measures
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305263/
https://www.ncbi.nlm.nih.gov/pubmed/35874951
http://dx.doi.org/10.7150/ijbs.72837
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