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Attachment status is associated with grey matter recovery in adolescent anorexia nervosa: Findings from a longitudinal study

The aim of the present study was to investigate whether grey matter (GM) reductions in acute anorexia nervosa (AN) are (i) valid for adolescents (age 14–18 years), (ii) reversible following short‐term psychotherapeutic and nutritional therapy and (iii) depend on psychological components like attachm...

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Autores principales: Lenhart, Lukas, Gander, Manuela, Steiger, Ruth, Dabkowska‐Mika, Angieszka, Mangesius, Stephanie, Haid‐Stecher, Nina, Fuchs, Martin, Buchheim, Anna, Sevecke, Kathrin, Gizewski, Elke Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305298/
https://www.ncbi.nlm.nih.gov/pubmed/35083790
http://dx.doi.org/10.1111/ejn.15614
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author Lenhart, Lukas
Gander, Manuela
Steiger, Ruth
Dabkowska‐Mika, Angieszka
Mangesius, Stephanie
Haid‐Stecher, Nina
Fuchs, Martin
Buchheim, Anna
Sevecke, Kathrin
Gizewski, Elke Ruth
author_facet Lenhart, Lukas
Gander, Manuela
Steiger, Ruth
Dabkowska‐Mika, Angieszka
Mangesius, Stephanie
Haid‐Stecher, Nina
Fuchs, Martin
Buchheim, Anna
Sevecke, Kathrin
Gizewski, Elke Ruth
author_sort Lenhart, Lukas
collection PubMed
description The aim of the present study was to investigate whether grey matter (GM) reductions in acute anorexia nervosa (AN) are (i) valid for adolescents (age 14–18 years), (ii) reversible following short‐term psychotherapeutic and nutritional therapy and (iii) depend on psychological components like attachment trauma. 3T MRI including a high‐resolution T1 MPRAGE was performed in 22 female adolescents in the acute state of AN (age: 15.2 ± 1.2 years) and after weight restoration (duration: 2.6 ± 1 months, n = 18) and compared with 18 gender‐matched healthy controls. The Adult Attachment Projective Picture System was used to classify resolved and unresolved attachment patterns. GM decreases were localized in extensive cortical areas including the insula, prefrontal and cingulate cortices as well as subcortical regions during acute AN, which partially increased after therapy with a relative sparing of the hippocampus and parahippocampal gyrus. The resolved group showed more GM recovery in regions of the left hippocampus and parahippocampal gyrus, bilateral cerebellar regions, right precuneus and adjacent cingulate cortices relative to the unresolved pattern. Structural anomalies in adolescent AN that recovered after treatment may be primarily the consequence of malnutrition, whereas several regions did not display significant recovery. Attachment status seems to influence region‐specific GM recovery.
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spelling pubmed-93052982022-07-28 Attachment status is associated with grey matter recovery in adolescent anorexia nervosa: Findings from a longitudinal study Lenhart, Lukas Gander, Manuela Steiger, Ruth Dabkowska‐Mika, Angieszka Mangesius, Stephanie Haid‐Stecher, Nina Fuchs, Martin Buchheim, Anna Sevecke, Kathrin Gizewski, Elke Ruth Eur J Neurosci Clinical and Translational Neuroscience The aim of the present study was to investigate whether grey matter (GM) reductions in acute anorexia nervosa (AN) are (i) valid for adolescents (age 14–18 years), (ii) reversible following short‐term psychotherapeutic and nutritional therapy and (iii) depend on psychological components like attachment trauma. 3T MRI including a high‐resolution T1 MPRAGE was performed in 22 female adolescents in the acute state of AN (age: 15.2 ± 1.2 years) and after weight restoration (duration: 2.6 ± 1 months, n = 18) and compared with 18 gender‐matched healthy controls. The Adult Attachment Projective Picture System was used to classify resolved and unresolved attachment patterns. GM decreases were localized in extensive cortical areas including the insula, prefrontal and cingulate cortices as well as subcortical regions during acute AN, which partially increased after therapy with a relative sparing of the hippocampus and parahippocampal gyrus. The resolved group showed more GM recovery in regions of the left hippocampus and parahippocampal gyrus, bilateral cerebellar regions, right precuneus and adjacent cingulate cortices relative to the unresolved pattern. Structural anomalies in adolescent AN that recovered after treatment may be primarily the consequence of malnutrition, whereas several regions did not display significant recovery. Attachment status seems to influence region‐specific GM recovery. John Wiley and Sons Inc. 2022-02-12 2022-03 /pmc/articles/PMC9305298/ /pubmed/35083790 http://dx.doi.org/10.1111/ejn.15614 Text en © 2022 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical and Translational Neuroscience
Lenhart, Lukas
Gander, Manuela
Steiger, Ruth
Dabkowska‐Mika, Angieszka
Mangesius, Stephanie
Haid‐Stecher, Nina
Fuchs, Martin
Buchheim, Anna
Sevecke, Kathrin
Gizewski, Elke Ruth
Attachment status is associated with grey matter recovery in adolescent anorexia nervosa: Findings from a longitudinal study
title Attachment status is associated with grey matter recovery in adolescent anorexia nervosa: Findings from a longitudinal study
title_full Attachment status is associated with grey matter recovery in adolescent anorexia nervosa: Findings from a longitudinal study
title_fullStr Attachment status is associated with grey matter recovery in adolescent anorexia nervosa: Findings from a longitudinal study
title_full_unstemmed Attachment status is associated with grey matter recovery in adolescent anorexia nervosa: Findings from a longitudinal study
title_short Attachment status is associated with grey matter recovery in adolescent anorexia nervosa: Findings from a longitudinal study
title_sort attachment status is associated with grey matter recovery in adolescent anorexia nervosa: findings from a longitudinal study
topic Clinical and Translational Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305298/
https://www.ncbi.nlm.nih.gov/pubmed/35083790
http://dx.doi.org/10.1111/ejn.15614
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