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The Role of Adipokines in Pancreatic Cancer

In modern society, inappropriate diets and other lifestyle habits have made obesity an increasingly prominent health problem. Pancreatic cancer (PC), a kind of highly aggressive malignant tumor, is known as a silent assassin and is the seventh leading cause of cancer death worldwide, pushing modern...

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Autores principales: Wang, Qi, Wang, Huizhi, Ding, Yuntao, Wan, Mengtian, Xu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305334/
https://www.ncbi.nlm.nih.gov/pubmed/35875143
http://dx.doi.org/10.3389/fonc.2022.926230
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author Wang, Qi
Wang, Huizhi
Ding, Yuntao
Wan, Mengtian
Xu, Min
author_facet Wang, Qi
Wang, Huizhi
Ding, Yuntao
Wan, Mengtian
Xu, Min
author_sort Wang, Qi
collection PubMed
description In modern society, inappropriate diets and other lifestyle habits have made obesity an increasingly prominent health problem. Pancreatic cancer (PC), a kind of highly aggressive malignant tumor, is known as a silent assassin and is the seventh leading cause of cancer death worldwide, pushing modern medicine beyond help. Adipokines are coming into notice because of the role of the intermediate regulatory junctions between obesity and malignancy. This review summarizes the current evidence for the relationship between highly concerning adipokines and the pathogenesis of PC. Not only are classical adipokines such as leptin and adiponectin included, but they also cover the recognized chemerin and osteopontin. Through a summary of the biological functions of these adipokines as well as their receptors, it was discovered that in addition to their basic function of stimulating the biological activity of tumors, more studies confirm that adipokines intervene in the progression of PC from the viewpoint of tumor metabolism, immune escape, and reprogramming of the tumor microenvironment (TME). Besides endocrine function, the impact of white adipose tissue (WAT)-induced chronic inflammation on PC is briefly discussed. Furthermore, the potential implication of the acknowledged endocrine behavior of brown adipose tissue (BAT) in relation to carcinogenesis is also explored. No matter the broad spectrum of obesity and the poor prognosis of PC, supplemental research is needed to unravel the detailed network of adipokines associated with PC. Exploiting profound therapeutic strategies that target adipokines and their receptors may go some way to improving the current worrying prognosis of PC patients.
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spelling pubmed-93053342022-07-23 The Role of Adipokines in Pancreatic Cancer Wang, Qi Wang, Huizhi Ding, Yuntao Wan, Mengtian Xu, Min Front Oncol Oncology In modern society, inappropriate diets and other lifestyle habits have made obesity an increasingly prominent health problem. Pancreatic cancer (PC), a kind of highly aggressive malignant tumor, is known as a silent assassin and is the seventh leading cause of cancer death worldwide, pushing modern medicine beyond help. Adipokines are coming into notice because of the role of the intermediate regulatory junctions between obesity and malignancy. This review summarizes the current evidence for the relationship between highly concerning adipokines and the pathogenesis of PC. Not only are classical adipokines such as leptin and adiponectin included, but they also cover the recognized chemerin and osteopontin. Through a summary of the biological functions of these adipokines as well as their receptors, it was discovered that in addition to their basic function of stimulating the biological activity of tumors, more studies confirm that adipokines intervene in the progression of PC from the viewpoint of tumor metabolism, immune escape, and reprogramming of the tumor microenvironment (TME). Besides endocrine function, the impact of white adipose tissue (WAT)-induced chronic inflammation on PC is briefly discussed. Furthermore, the potential implication of the acknowledged endocrine behavior of brown adipose tissue (BAT) in relation to carcinogenesis is also explored. No matter the broad spectrum of obesity and the poor prognosis of PC, supplemental research is needed to unravel the detailed network of adipokines associated with PC. Exploiting profound therapeutic strategies that target adipokines and their receptors may go some way to improving the current worrying prognosis of PC patients. Frontiers Media S.A. 2022-07-08 /pmc/articles/PMC9305334/ /pubmed/35875143 http://dx.doi.org/10.3389/fonc.2022.926230 Text en Copyright © 2022 Wang, Wang, Ding, Wan and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Qi
Wang, Huizhi
Ding, Yuntao
Wan, Mengtian
Xu, Min
The Role of Adipokines in Pancreatic Cancer
title The Role of Adipokines in Pancreatic Cancer
title_full The Role of Adipokines in Pancreatic Cancer
title_fullStr The Role of Adipokines in Pancreatic Cancer
title_full_unstemmed The Role of Adipokines in Pancreatic Cancer
title_short The Role of Adipokines in Pancreatic Cancer
title_sort role of adipokines in pancreatic cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305334/
https://www.ncbi.nlm.nih.gov/pubmed/35875143
http://dx.doi.org/10.3389/fonc.2022.926230
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