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Nuclear protein quality control in yeast: The latest INQuiries

The nucleus is a highly organized organelle with an intricate substructure of chromatin, RNAs, and proteins. This environment represents a challenge for maintaining protein quality control, since non-native proteins may interact inappropriately with other macromolecules and thus interfere with their...

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Detalles Bibliográficos
Autores principales: Kumar, Arun, Mathew, Veena, Stirling, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305344/
https://www.ncbi.nlm.nih.gov/pubmed/35760103
http://dx.doi.org/10.1016/j.jbc.2022.102199
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author Kumar, Arun
Mathew, Veena
Stirling, Peter C.
author_facet Kumar, Arun
Mathew, Veena
Stirling, Peter C.
author_sort Kumar, Arun
collection PubMed
description The nucleus is a highly organized organelle with an intricate substructure of chromatin, RNAs, and proteins. This environment represents a challenge for maintaining protein quality control, since non-native proteins may interact inappropriately with other macromolecules and thus interfere with their function. Maintaining a healthy nuclear proteome becomes imperative during times of stress, such as upon DNA damage, heat shock, or starvation, when the proteome must be remodeled to effect cell survival. This is accomplished with the help of nuclear-specific chaperones, degradation pathways, and specialized structures known as protein quality control (PQC) sites that sequester proteins to help rapidly remodel the nuclear proteome. In this review, we focus on the current knowledge of PQC sites in Saccharomyces cerevisiae, particularly on a specialized nuclear PQC site called the intranuclear quality control site, a poorly understood nuclear inclusion that coordinates dynamic proteome triage decisions in yeast.
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spelling pubmed-93053442022-07-25 Nuclear protein quality control in yeast: The latest INQuiries Kumar, Arun Mathew, Veena Stirling, Peter C. J Biol Chem JBC Reviews The nucleus is a highly organized organelle with an intricate substructure of chromatin, RNAs, and proteins. This environment represents a challenge for maintaining protein quality control, since non-native proteins may interact inappropriately with other macromolecules and thus interfere with their function. Maintaining a healthy nuclear proteome becomes imperative during times of stress, such as upon DNA damage, heat shock, or starvation, when the proteome must be remodeled to effect cell survival. This is accomplished with the help of nuclear-specific chaperones, degradation pathways, and specialized structures known as protein quality control (PQC) sites that sequester proteins to help rapidly remodel the nuclear proteome. In this review, we focus on the current knowledge of PQC sites in Saccharomyces cerevisiae, particularly on a specialized nuclear PQC site called the intranuclear quality control site, a poorly understood nuclear inclusion that coordinates dynamic proteome triage decisions in yeast. American Society for Biochemistry and Molecular Biology 2022-06-24 /pmc/articles/PMC9305344/ /pubmed/35760103 http://dx.doi.org/10.1016/j.jbc.2022.102199 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle JBC Reviews
Kumar, Arun
Mathew, Veena
Stirling, Peter C.
Nuclear protein quality control in yeast: The latest INQuiries
title Nuclear protein quality control in yeast: The latest INQuiries
title_full Nuclear protein quality control in yeast: The latest INQuiries
title_fullStr Nuclear protein quality control in yeast: The latest INQuiries
title_full_unstemmed Nuclear protein quality control in yeast: The latest INQuiries
title_short Nuclear protein quality control in yeast: The latest INQuiries
title_sort nuclear protein quality control in yeast: the latest inquiries
topic JBC Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305344/
https://www.ncbi.nlm.nih.gov/pubmed/35760103
http://dx.doi.org/10.1016/j.jbc.2022.102199
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