Immune aging in multiple sclerosis is characterized by abnormal CD4 T cell activation and increased frequencies of cytotoxic CD4 T cells with advancing age

BACKGROUND: Immunosenescence (ISC) describes age-related changes in immune-system composition and function. Multiple sclerosis (MS) is a lifelong inflammatory condition involving effector and regulatory T-cell imbalance, yet little is known about T-cell ISC in MS. We examined age-associated changes...

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Detalles Bibliográficos
Autores principales: Zuroff, Leah, Rezk, Ayman, Shinoda, Koji, Espinoza, Diego A., Elyahu, Yehezqel, Zhang, Bo, Chen, Andrew A., Shinohara, Russell T., Jacobs, Dina, Alcalay, Roy N., Tropea, Thomas F., Chen-Plotkin, Alice, Monsonego, Alon, Li, Rui, Bar-Or, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305354/
https://www.ncbi.nlm.nih.gov/pubmed/35868128
http://dx.doi.org/10.1016/j.ebiom.2022.104179

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