Cargando…

Clinical, Cellular, and Molecular Effects of Corticosteroids on the Response to Intradermal Lipopolysaccharide Administration in Healthy Volunteers

The intradermal lipopolysaccharide (LPS) challenge in healthy volunteers has proven to be a valuable tool to study local inflammation in vivo. In the current study the inhibitory effects of oral and topical corticosteroid treatment on intradermal LPS responses were evaluated to benchmark the challen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Buters, Thomas P., Hameeteman, Pieter W., Jansen, Iris M.E., van Hindevoort, Floris C., ten Voorde, Wouter, Grievink, Hendrika W., Schoonakker, Mascha, de Kam, Marieke L., Gilroy, Derek W., Feiss, Gary, Rissmann, Robert, Jansen, Manon A.A., Burggraaf, Jacobus, Moerland, Matthijs
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305467/ https://www.ncbi.nlm.nih.gov/pubmed/34935141 http://dx.doi.org/10.1002/cpt.2516

Ejemplares similares

Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers
por: Buters, Thomas P., et al.
Publicado: (2021)

Antimicrobial Peptide Omiganan Enhances Interferon Responses to Endosomal Toll‐Like Receptor Ligands in Human Peripheral Blood Mononuclear Cells
por: Grievink, Hendrika W., et al.
Publicado: (2020)

Comprehensive evaluation of microneedle‐based intradermal adalimumab delivery vs. subcutaneous administration: results of a randomized controlled clinical trial
por: Jacobse, Justin, et al.
Publicado: (2021)

Monitoring of Ex Vivo Cyclosporin a Activity in Healthy Volunteers Using T Cell Function Assays in Relation to Whole Blood and Cellular Pharmacokinetics
por: in ’t Veld, Aliede E., et al.
Publicado: (2022)

Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study
por: in ‘t Veld, Aliede E., et al.
Publicado: (2023)

The Effect of a 13-Valent Conjugate Pneumococcal Vaccine on Circulating Antibodies Against Oxidized LDL and Phosphorylcholine in Man, A Randomized Placebo-Controlled Clinical Trial
por: Grievink, Hendrika W., et al.
Publicado: (2020)

Whole blood assay as a model for in vitro evaluation of inflammasome activation and subsequent caspase-mediated interleukin-1 beta release
por: Tran, Thi Anh Thu, et al.
Publicado: (2019)

Omiganan Enhances Imiquimod‐Induced Inflammatory Responses in Skin of Healthy Volunteers
por: Niemeyer‐van der Kolk, Tessa, et al.
Publicado: (2020)

Immunomonitoring of Tacrolimus in Healthy Volunteers: The First Step from PK- to PD-Based Therapeutic Drug Monitoring?
por: in ‘t Veld, Aliede E., et al.
Publicado: (2019)

Oral prednisolone suppresses skin inflammation in a healthy volunteer imiquimod challenge model
por: Assil, Salma, et al.
Publicado: (2023)

OX40L Inhibition Suppresses KLH‐driven Immune Responses in Healthy Volunteers: A Randomized Controlled Trial Demonstrating Proof‐of‐Pharmacology for KY1005
por: Saghari, Mahdi, et al.
Publicado: (2022)

Novel SGLT2 inhibitor: first‐in‐man studies of antisense compound is associated with unexpected renal effects
por: van Meer, Leonie, et al.
Publicado: (2017)

Comprehensive, Multimodal Characterization of an Imiquimod‐Induced Human Skin Inflammation Model for Drug Development
por: van der Kolk, Tessa, et al.
Publicado: (2018)

Immune Monitoring of Mycophenolate Mofetil Activity in Healthy Volunteers Using Ex Vivo T Cell Function Assays
por: in ’t Veld, Aliede E., et al.
Publicado: (2023)

Impact of oral administration of single strain Lactococcus lactis spp. cremoris on immune responses to keyhole limpet hemocyanin immunization and gut microbiota: A randomized placebo-controlled trial in healthy volunteers
por: Saghari, Mahdi, et al.
Publicado: (2022)

Remarkable Pharmacokinetics of Monoclonal Antibodies: A Quest for an Explanation
por: Reijers, Joannes A. A., et al.
Publicado: (2016)

The effect of repeated methotrexate injections on the quality of life of children with rheumatic diseases
por: Jacobse, Justin, et al.
Publicado: (2018)

A randomized controlled trial with a delayed‐type hypersensitivity model using keyhole limpet haemocyanin to evaluate adaptive immune responses in man
por: Saghari, Mahdi, et al.
Publicado: (2020)

Sample Aging Profoundly Reduces Monocyte Responses in Human Whole Blood Cultures
por: Grievink, H. W., et al.
Publicado: (2018)

Under‐representation of elderly in clinical trials: An analysis of the initial approval documents in the Food and Drug Administration database
por: Ruiter, Rikje, et al.
Publicado: (2019)

Intradermal substance P as a challenge agent in healthy individuals
por: ten Voorde, Wouter, et al.
Publicado: (2023)

Hydroxychloroquine Effects on TLR Signalling: Underexposed but Unneglectable in COVID-19
por: in ‘t Veld, Aliede E., et al.
Publicado: (2021)

Erratum to “Hydroxychloroquine Effects on TLR Signalling: Underexposed but Unneglectable in COVID-19”
por: in ‘t Veld, Aliede E., et al.
Publicado: (2021)

Blueprint for mechanistic, data‐rich early phase clinical pharmacology studies in dermatology
por: Rissmann, Robert, et al.
Publicado: (2020)

Potential Influence of Endothelial Adsorption on the Delayed Time to Maximum Concentration of Biopharmaceuticals
por: Reijers, Joannes A. A., et al.
Publicado: (2017)

Adverse immunostimulation caused by impurities: The dark side of biopharmaceuticals
por: Reijers, Joannes A. A., et al.
Publicado: (2019)

A randomized single and multiple ascending dose study in healthy volunteers of LTI‐291, a centrally penetrant glucocerebrosidase activator
por: den Heijer, Jonas M., et al.
Publicado: (2021)

Stimulation of the PD-1 Pathway Decreases Atherosclerotic Lesion Development in Ldlr Deficient Mice
por: Grievink, Hendrika W., et al.
Publicado: (2021)

Integration of healthy volunteers in early phase clinical trials with immuno-oncological compounds
por: Radanovic, Igor, et al.
Publicado: (2022)

Inter- and Intra-patient Variability Over Time of Lesional Skin Microbiota in Adult Patients with Atopic Dermatitis
por: VAN DEN MUNCKHOF, Ellen H. A., et al.
Publicado: (2020)

Treatment with the Topical Antimicrobial Peptide Omiganan in Mild-to-Moderate Facial Seborrheic Dermatitis versus Ketoconazole and Placebo: Results of a Randomized Controlled Proof-of-Concept Trial
por: Rousel, Jannik, et al.
Publicado: (2023)

Gender differences in clinical registration trials: is there a real problem?
por: Labots, Geert, et al.
Publicado: (2018)

Clinical Evaluation of Humira(®) Biosimilar ONS-3010 in Healthy Volunteers: Focus on Pharmacokinetics and Pharmacodynamics
por: Dillingh, Marlous R., et al.
Publicado: (2016)

Pharmacodynamic Effects of Topical Omiganan in Patients With Mild to Moderate Atopic Dermatitis in a Randomized, Placebo‐Controlled, Phase II Trial
por: Niemeyer‐van der Kolk, Tessa, et al.
Publicado: (2020)

Assessment of dermal absorption of aluminium from a representative antiperspirant formulation using a ((26)Al)Al microtracer approach: a follow-up study in humans
por: de Ligt, Rianne, et al.
Publicado: (2022)

Trastuzumab Induces an Immediate, Transient Volume Increase in Humans: A Randomised Placebo-Controlled Trial
por: Reijers, Joannes A.A., et al.
Publicado: (2015)

Stability analysis of clustering of Norris’ visual analogue scale: Applying the consensus clustering approach
por: Guan, Zheng, et al.
Publicado: (2021)

A randomized controlled proof‐of‐concept trial of digoxin and furosemide in adults with cutaneous warts
por: Rijsbergen, M., et al.
Publicado: (2019)

INTRADERMAL VERSUS SUBCUTANEOUS IMMUNIZATION OF MONKEYS AGAINST POLIOMYELITIS
por: Stewart, F. W., et al.
Publicado: (1929)

Integrin αvβ6 as a Target for Tumor-Specific Imaging of Vulvar Squamous Cell Carcinoma and Adjacent Premalignant Lesions
por: Huisman, Bertine W., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_d8aqfeodrtngcctaau9rbh70ck