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Osteosarcoma mechanobiology and therapeutic targets

Osteosarcoma is one of the most common primary tumours of the bone, with a 5‐year survival rate of less than 20% after the development of metastases. Osteosarcoma is highly predisposed in Paget's disease of the bone, and both have common characteristic skeletal features due to rapid bone remode...

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Autores principales: Shoaib, Zunaira, Fan, Timothy M., Irudayaraj, Joseph M. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305477/
https://www.ncbi.nlm.nih.gov/pubmed/34679192
http://dx.doi.org/10.1111/bph.15713
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author Shoaib, Zunaira
Fan, Timothy M.
Irudayaraj, Joseph M. K.
author_facet Shoaib, Zunaira
Fan, Timothy M.
Irudayaraj, Joseph M. K.
author_sort Shoaib, Zunaira
collection PubMed
description Osteosarcoma is one of the most common primary tumours of the bone, with a 5‐year survival rate of less than 20% after the development of metastases. Osteosarcoma is highly predisposed in Paget's disease of the bone, and both have common characteristic skeletal features due to rapid bone remodelling. Osteosarcoma prognosis is location dependent, which further emphasizes the likely contribution of the bone microenvironment in its pathogenesis. Mechanobiology describes the processes involved when mechanical cues from the changing physical microenvironment of the bone are transduced to biological pathways through mechanosensitive cellular components. Mechanobiology‐driven therapies have been used to curb tumour progression by direct alteration of the physical microenvironment or inhibition of metastasis‐associated mechanosensitive proteins. This review emphasizes the contribution of mechanobiology to the progression of osteosarcoma and sheds light on current mechanobiology‐based therapies and potential new targets for improving disease management. Additionally, the many different 3D models currently used to study osteosarcoma mechanobiology are summarized.
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spelling pubmed-93054772022-07-28 Osteosarcoma mechanobiology and therapeutic targets Shoaib, Zunaira Fan, Timothy M. Irudayaraj, Joseph M. K. Br J Pharmacol Review Article Osteosarcoma is one of the most common primary tumours of the bone, with a 5‐year survival rate of less than 20% after the development of metastases. Osteosarcoma is highly predisposed in Paget's disease of the bone, and both have common characteristic skeletal features due to rapid bone remodelling. Osteosarcoma prognosis is location dependent, which further emphasizes the likely contribution of the bone microenvironment in its pathogenesis. Mechanobiology describes the processes involved when mechanical cues from the changing physical microenvironment of the bone are transduced to biological pathways through mechanosensitive cellular components. Mechanobiology‐driven therapies have been used to curb tumour progression by direct alteration of the physical microenvironment or inhibition of metastasis‐associated mechanosensitive proteins. This review emphasizes the contribution of mechanobiology to the progression of osteosarcoma and sheds light on current mechanobiology‐based therapies and potential new targets for improving disease management. Additionally, the many different 3D models currently used to study osteosarcoma mechanobiology are summarized. John Wiley and Sons Inc. 2021-12-21 2022-01 /pmc/articles/PMC9305477/ /pubmed/34679192 http://dx.doi.org/10.1111/bph.15713 Text en © 2021 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review Article
Shoaib, Zunaira
Fan, Timothy M.
Irudayaraj, Joseph M. K.
Osteosarcoma mechanobiology and therapeutic targets
title Osteosarcoma mechanobiology and therapeutic targets
title_full Osteosarcoma mechanobiology and therapeutic targets
title_fullStr Osteosarcoma mechanobiology and therapeutic targets
title_full_unstemmed Osteosarcoma mechanobiology and therapeutic targets
title_short Osteosarcoma mechanobiology and therapeutic targets
title_sort osteosarcoma mechanobiology and therapeutic targets
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305477/
https://www.ncbi.nlm.nih.gov/pubmed/34679192
http://dx.doi.org/10.1111/bph.15713
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