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The effectiveness of skeletal muscle evaluation at the third cervical vertebral level for computed tomography‐defined sarcopenia assessment in patients with head and neck cancer

BACKGROUND: Computed tomography (CT)‐defined sarcopenia is a prognostic indicator in head and neck cancer (HNC), with the gold standard for muscle evaluation using cross‐sectional area (CSA) at the third lumbar vertebra (L3). We compared methods using CSA at the third cervical vertebra (C3). METHODS...

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Autores principales: Vangelov, Belinda, Bauer, Judith, Moses, Daniel, Smee, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305498/
https://www.ncbi.nlm.nih.gov/pubmed/35138008
http://dx.doi.org/10.1002/hed.27000
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author Vangelov, Belinda
Bauer, Judith
Moses, Daniel
Smee, Robert
author_facet Vangelov, Belinda
Bauer, Judith
Moses, Daniel
Smee, Robert
author_sort Vangelov, Belinda
collection PubMed
description BACKGROUND: Computed tomography (CT)‐defined sarcopenia is a prognostic indicator in head and neck cancer (HNC), with the gold standard for muscle evaluation using cross‐sectional area (CSA) at the third lumbar vertebra (L3). We compared methods using CSA at the third cervical vertebra (C3). METHODS: Muscle CSA was measured at L3, and CSA at C3 was used to estimate L3 CSA using a prediction model. Agreement and sarcopenia diagnosis were evaluated. RESULTS: Good correlation was found between measured and estimated CSA (101 scans; r = 0.86, p < 0.001). CSA mean difference (bias) 9.99 cm(2), (SD = 20.3 cm(2)). Skeletal muscle index bias 5.85% (SD = 13.4%), 95% limits of agreement (LoA) (−20.4 to 32.1%, r = 0.29), exceeded clinically accepted limits of 5%. Sarcopenia was diagnosed in 26%‐(L3), 45%‐(C3), with weak agreement (ƙ = 0.368, 95% confidence interval, 0.192–0.544, p < 0.001) (sensitivity 79.2%, specificity 66.7%). CONCLUSION: Agreement between measures was weak. Widespread LoA, proportional bias, and sarcopenia misclassification indicates that estimates using C3 cannot replace actual measures at L3.
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spelling pubmed-93054982022-07-28 The effectiveness of skeletal muscle evaluation at the third cervical vertebral level for computed tomography‐defined sarcopenia assessment in patients with head and neck cancer Vangelov, Belinda Bauer, Judith Moses, Daniel Smee, Robert Head Neck Original Articles BACKGROUND: Computed tomography (CT)‐defined sarcopenia is a prognostic indicator in head and neck cancer (HNC), with the gold standard for muscle evaluation using cross‐sectional area (CSA) at the third lumbar vertebra (L3). We compared methods using CSA at the third cervical vertebra (C3). METHODS: Muscle CSA was measured at L3, and CSA at C3 was used to estimate L3 CSA using a prediction model. Agreement and sarcopenia diagnosis were evaluated. RESULTS: Good correlation was found between measured and estimated CSA (101 scans; r = 0.86, p < 0.001). CSA mean difference (bias) 9.99 cm(2), (SD = 20.3 cm(2)). Skeletal muscle index bias 5.85% (SD = 13.4%), 95% limits of agreement (LoA) (−20.4 to 32.1%, r = 0.29), exceeded clinically accepted limits of 5%. Sarcopenia was diagnosed in 26%‐(L3), 45%‐(C3), with weak agreement (ƙ = 0.368, 95% confidence interval, 0.192–0.544, p < 0.001) (sensitivity 79.2%, specificity 66.7%). CONCLUSION: Agreement between measures was weak. Widespread LoA, proportional bias, and sarcopenia misclassification indicates that estimates using C3 cannot replace actual measures at L3. John Wiley & Sons, Inc. 2022-02-09 2022-05 /pmc/articles/PMC9305498/ /pubmed/35138008 http://dx.doi.org/10.1002/hed.27000 Text en © 2022 The Authors. Head & Neck published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Vangelov, Belinda
Bauer, Judith
Moses, Daniel
Smee, Robert
The effectiveness of skeletal muscle evaluation at the third cervical vertebral level for computed tomography‐defined sarcopenia assessment in patients with head and neck cancer
title The effectiveness of skeletal muscle evaluation at the third cervical vertebral level for computed tomography‐defined sarcopenia assessment in patients with head and neck cancer
title_full The effectiveness of skeletal muscle evaluation at the third cervical vertebral level for computed tomography‐defined sarcopenia assessment in patients with head and neck cancer
title_fullStr The effectiveness of skeletal muscle evaluation at the third cervical vertebral level for computed tomography‐defined sarcopenia assessment in patients with head and neck cancer
title_full_unstemmed The effectiveness of skeletal muscle evaluation at the third cervical vertebral level for computed tomography‐defined sarcopenia assessment in patients with head and neck cancer
title_short The effectiveness of skeletal muscle evaluation at the third cervical vertebral level for computed tomography‐defined sarcopenia assessment in patients with head and neck cancer
title_sort effectiveness of skeletal muscle evaluation at the third cervical vertebral level for computed tomography‐defined sarcopenia assessment in patients with head and neck cancer
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305498/
https://www.ncbi.nlm.nih.gov/pubmed/35138008
http://dx.doi.org/10.1002/hed.27000
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