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The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries
DNA‐encoded library (DEL) technology has become widely used in drug discovery research. The construction of DELs requires robust organic transformations that proceed in aqueous media under mild conditions. Unfortunately, the application of water as reaction medium for organic synthesis is not eviden...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305553/ https://www.ncbi.nlm.nih.gov/pubmed/35019168 http://dx.doi.org/10.1002/chem.202103967 |
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author | Adamik, Réka Buchholcz, Balázs Darvas, Ferenc Sipos, Gellért Novák, Zoltán |
author_facet | Adamik, Réka Buchholcz, Balázs Darvas, Ferenc Sipos, Gellért Novák, Zoltán |
author_sort | Adamik, Réka |
collection | PubMed |
description | DNA‐encoded library (DEL) technology has become widely used in drug discovery research. The construction of DELs requires robust organic transformations that proceed in aqueous media under mild conditions. Unfortunately, the application of water as reaction medium for organic synthesis is not evident due to the generally limited solubility of organic reagents. However, the use of surfactants can offer a solution to this issue. Oil‐in‐water microemulsions formed by surfactant micelles are able to localize hydrophobic reagents inside them, resulting in high local concentrations of the organic substances in an otherwise poorly solvated environment. This review provides a conceptual and critical summary of micellar synthesis possibilities that are well suited to DEL synthesis. Existing examples of micellar DEL approaches, together with a selection of micellar organic transformations fundamentally suitable for DEL are discussed. |
format | Online Article Text |
id | pubmed-9305553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93055532022-07-28 The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries Adamik, Réka Buchholcz, Balázs Darvas, Ferenc Sipos, Gellért Novák, Zoltán Chemistry Reviews DNA‐encoded library (DEL) technology has become widely used in drug discovery research. The construction of DELs requires robust organic transformations that proceed in aqueous media under mild conditions. Unfortunately, the application of water as reaction medium for organic synthesis is not evident due to the generally limited solubility of organic reagents. However, the use of surfactants can offer a solution to this issue. Oil‐in‐water microemulsions formed by surfactant micelles are able to localize hydrophobic reagents inside them, resulting in high local concentrations of the organic substances in an otherwise poorly solvated environment. This review provides a conceptual and critical summary of micellar synthesis possibilities that are well suited to DEL synthesis. Existing examples of micellar DEL approaches, together with a selection of micellar organic transformations fundamentally suitable for DEL are discussed. John Wiley and Sons Inc. 2022-02-14 2022-04-06 /pmc/articles/PMC9305553/ /pubmed/35019168 http://dx.doi.org/10.1002/chem.202103967 Text en © 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Adamik, Réka Buchholcz, Balázs Darvas, Ferenc Sipos, Gellért Novák, Zoltán The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries |
title | The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries |
title_full | The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries |
title_fullStr | The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries |
title_full_unstemmed | The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries |
title_short | The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries |
title_sort | potential of micellar media in the synthesis of dna‐encoded libraries |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305553/ https://www.ncbi.nlm.nih.gov/pubmed/35019168 http://dx.doi.org/10.1002/chem.202103967 |
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