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The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries

DNA‐encoded library (DEL) technology has become widely used in drug discovery research. The construction of DELs requires robust organic transformations that proceed in aqueous media under mild conditions. Unfortunately, the application of water as reaction medium for organic synthesis is not eviden...

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Autores principales: Adamik, Réka, Buchholcz, Balázs, Darvas, Ferenc, Sipos, Gellért, Novák, Zoltán
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305553/
https://www.ncbi.nlm.nih.gov/pubmed/35019168
http://dx.doi.org/10.1002/chem.202103967
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author Adamik, Réka
Buchholcz, Balázs
Darvas, Ferenc
Sipos, Gellért
Novák, Zoltán
author_facet Adamik, Réka
Buchholcz, Balázs
Darvas, Ferenc
Sipos, Gellért
Novák, Zoltán
author_sort Adamik, Réka
collection PubMed
description DNA‐encoded library (DEL) technology has become widely used in drug discovery research. The construction of DELs requires robust organic transformations that proceed in aqueous media under mild conditions. Unfortunately, the application of water as reaction medium for organic synthesis is not evident due to the generally limited solubility of organic reagents. However, the use of surfactants can offer a solution to this issue. Oil‐in‐water microemulsions formed by surfactant micelles are able to localize hydrophobic reagents inside them, resulting in high local concentrations of the organic substances in an otherwise poorly solvated environment. This review provides a conceptual and critical summary of micellar synthesis possibilities that are well suited to DEL synthesis. Existing examples of micellar DEL approaches, together with a selection of micellar organic transformations fundamentally suitable for DEL are discussed.
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spelling pubmed-93055532022-07-28 The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries Adamik, Réka Buchholcz, Balázs Darvas, Ferenc Sipos, Gellért Novák, Zoltán Chemistry Reviews DNA‐encoded library (DEL) technology has become widely used in drug discovery research. The construction of DELs requires robust organic transformations that proceed in aqueous media under mild conditions. Unfortunately, the application of water as reaction medium for organic synthesis is not evident due to the generally limited solubility of organic reagents. However, the use of surfactants can offer a solution to this issue. Oil‐in‐water microemulsions formed by surfactant micelles are able to localize hydrophobic reagents inside them, resulting in high local concentrations of the organic substances in an otherwise poorly solvated environment. This review provides a conceptual and critical summary of micellar synthesis possibilities that are well suited to DEL synthesis. Existing examples of micellar DEL approaches, together with a selection of micellar organic transformations fundamentally suitable for DEL are discussed. John Wiley and Sons Inc. 2022-02-14 2022-04-06 /pmc/articles/PMC9305553/ /pubmed/35019168 http://dx.doi.org/10.1002/chem.202103967 Text en © 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Adamik, Réka
Buchholcz, Balázs
Darvas, Ferenc
Sipos, Gellért
Novák, Zoltán
The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries
title The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries
title_full The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries
title_fullStr The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries
title_full_unstemmed The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries
title_short The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries
title_sort potential of micellar media in the synthesis of dna‐encoded libraries
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305553/
https://www.ncbi.nlm.nih.gov/pubmed/35019168
http://dx.doi.org/10.1002/chem.202103967
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