Roles of Non-Coding RNAs in Primary Biliary Cholangitis

Primary biliary cholangitis (PBC) is an autoimmune-mediated chronic cholestatic liver disease, fatigue, and skin itching are the most common clinical symptoms. Its main pathological feature is the progressive damage and destruction of bile duct epithelial cells. Non-coding RNA (NcRNA, mainly includi...

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Autores principales: Zhang, Yaqin, Jiao, Ziying, Chen, Mingwei, Shen, Bing, Shuai, Zongwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305664/
https://www.ncbi.nlm.nih.gov/pubmed/35874606
http://dx.doi.org/10.3389/fmolb.2022.915993
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author Zhang, Yaqin
Jiao, Ziying
Chen, Mingwei
Shen, Bing
Shuai, Zongwen
author_facet Zhang, Yaqin
Jiao, Ziying
Chen, Mingwei
Shen, Bing
Shuai, Zongwen
author_sort Zhang, Yaqin
collection PubMed
description Primary biliary cholangitis (PBC) is an autoimmune-mediated chronic cholestatic liver disease, fatigue, and skin itching are the most common clinical symptoms. Its main pathological feature is the progressive damage and destruction of bile duct epithelial cells. Non-coding RNA (NcRNA, mainly including microRNA, long non-coding RNA and circular RNA) plays a role in the pathological and biological processes of various diseases, especially autoimmune diseases. Many validated ncRNAs are expected to be biomarkers for the diagnosis or treatment of PBC. This review will elucidate the pathogenesis of PBC and help to identify potential ncRNA biomarkers for PBC.
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spelling pubmed-93056642022-07-23 Roles of Non-Coding RNAs in Primary Biliary Cholangitis Zhang, Yaqin Jiao, Ziying Chen, Mingwei Shen, Bing Shuai, Zongwen Front Mol Biosci Molecular Biosciences Primary biliary cholangitis (PBC) is an autoimmune-mediated chronic cholestatic liver disease, fatigue, and skin itching are the most common clinical symptoms. Its main pathological feature is the progressive damage and destruction of bile duct epithelial cells. Non-coding RNA (NcRNA, mainly including microRNA, long non-coding RNA and circular RNA) plays a role in the pathological and biological processes of various diseases, especially autoimmune diseases. Many validated ncRNAs are expected to be biomarkers for the diagnosis or treatment of PBC. This review will elucidate the pathogenesis of PBC and help to identify potential ncRNA biomarkers for PBC. Frontiers Media S.A. 2022-07-08 /pmc/articles/PMC9305664/ /pubmed/35874606 http://dx.doi.org/10.3389/fmolb.2022.915993 Text en Copyright © 2022 Zhang, Jiao, Chen, Shen and Shuai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Zhang, Yaqin
Jiao, Ziying
Chen, Mingwei
Shen, Bing
Shuai, Zongwen
Roles of Non-Coding RNAs in Primary Biliary Cholangitis
title Roles of Non-Coding RNAs in Primary Biliary Cholangitis
title_full Roles of Non-Coding RNAs in Primary Biliary Cholangitis
title_fullStr Roles of Non-Coding RNAs in Primary Biliary Cholangitis
title_full_unstemmed Roles of Non-Coding RNAs in Primary Biliary Cholangitis
title_short Roles of Non-Coding RNAs in Primary Biliary Cholangitis
title_sort roles of non-coding rnas in primary biliary cholangitis
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305664/
https://www.ncbi.nlm.nih.gov/pubmed/35874606
http://dx.doi.org/10.3389/fmolb.2022.915993
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