Titanocene(III)‐Catalyzed Precision Deuteration of Epoxides

We describe a titanocene(III)‐catalyzed deuterosilylation of epoxides that provides β‐deuterated anti‐Markovnikov alcohols with excellent D‐incorporation, in high yield, and often excellent diastereoselectivity after desilylation. The key to the success of the reaction is a novel activation method o...

Descripción completa

Detalles Bibliográficos
Autores principales: Henriques, Dina Schwarz G., Rojo‐Wiechel, Elena, Klare, Sven, Mika, Regine, Höthker, Sebastian, Schacht, Jonathan H., Schmickler, Niklas, Gansäuer, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305931/
https://www.ncbi.nlm.nih.gov/pubmed/34845824
http://dx.doi.org/10.1002/anie.202114198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305931/
https://www.ncbi.nlm.nih.gov/pubmed/34845824
http://dx.doi.org/10.1002/anie.202114198

Ejemplares similares