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Peripheral nerve morphology and intraneural blood flow in chronic kidney disease with and without diabetes
INTRODUCTION/AIMS: Sonographic alterations of peripheral nerves in pre‐dialytic kidney disease are yet to be determined. We aimed to assess peripheral nerve cross‐sectional area (CSA) and intraneural blood flow in patients with pre‐dialytic chronic kidney disease (CKD) and diabetic kidney disease (D...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305967/ https://www.ncbi.nlm.nih.gov/pubmed/35119701 http://dx.doi.org/10.1002/mus.27513 |
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author | Issar, Tushar Walker, Susan Arnold, Ria Poynten, Ann M. Endre, Zoltan H. Krishnan, Arun V. |
author_facet | Issar, Tushar Walker, Susan Arnold, Ria Poynten, Ann M. Endre, Zoltan H. Krishnan, Arun V. |
author_sort | Issar, Tushar |
collection | PubMed |
description | INTRODUCTION/AIMS: Sonographic alterations of peripheral nerves in pre‐dialytic kidney disease are yet to be determined. We aimed to assess peripheral nerve cross‐sectional area (CSA) and intraneural blood flow in patients with pre‐dialytic chronic kidney disease (CKD) and diabetic kidney disease (DKD). METHODS: Subjects with CKD (n = 20) or DKD (n = 20) underwent ultrasound to assess CSA of the median and tibial nerves as well as intraneural blood flow of the median nerve. Blood flow was quantified using maximum perfusion intensity. Neuropathy was assessed using the Total Neuropathy Score. A 6‐m timed walk test was also performed. Healthy controls (n = 28) were recruited for comparison. RESULTS: The DKD group had more severe neuropathy (p = .024), larger tibial nerve CSA (p = .002) and greater median nerve blood flow than the CKD group (p = .023). Blood flow correlated with serum potassium in disease groups (r = 0.652, p = .022). Disease groups had larger tibial nerve CSA than controls (p < .05). No blood flow was detected in controls. Tibial nerve enlargement was associated with slower maximal walking speeds in disease groups (r = −0.389, p = .021). DISCUSSION: Subjects with DKD demonstrated enlarged tibial nerve CSA and increased median nerve blood flow compared to those with CKD. Elevations in serum potassium were associated with increased blood flow. Sonographic alterations were detectable in pre‐dialytic kidney disease compared to controls, highlighting the utility of ultrasound in the assessment of nerve pathology in these patient groups. |
format | Online Article Text |
id | pubmed-9305967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93059672022-07-28 Peripheral nerve morphology and intraneural blood flow in chronic kidney disease with and without diabetes Issar, Tushar Walker, Susan Arnold, Ria Poynten, Ann M. Endre, Zoltan H. Krishnan, Arun V. Muscle Nerve Clinical Research Short Reports INTRODUCTION/AIMS: Sonographic alterations of peripheral nerves in pre‐dialytic kidney disease are yet to be determined. We aimed to assess peripheral nerve cross‐sectional area (CSA) and intraneural blood flow in patients with pre‐dialytic chronic kidney disease (CKD) and diabetic kidney disease (DKD). METHODS: Subjects with CKD (n = 20) or DKD (n = 20) underwent ultrasound to assess CSA of the median and tibial nerves as well as intraneural blood flow of the median nerve. Blood flow was quantified using maximum perfusion intensity. Neuropathy was assessed using the Total Neuropathy Score. A 6‐m timed walk test was also performed. Healthy controls (n = 28) were recruited for comparison. RESULTS: The DKD group had more severe neuropathy (p = .024), larger tibial nerve CSA (p = .002) and greater median nerve blood flow than the CKD group (p = .023). Blood flow correlated with serum potassium in disease groups (r = 0.652, p = .022). Disease groups had larger tibial nerve CSA than controls (p < .05). No blood flow was detected in controls. Tibial nerve enlargement was associated with slower maximal walking speeds in disease groups (r = −0.389, p = .021). DISCUSSION: Subjects with DKD demonstrated enlarged tibial nerve CSA and increased median nerve blood flow compared to those with CKD. Elevations in serum potassium were associated with increased blood flow. Sonographic alterations were detectable in pre‐dialytic kidney disease compared to controls, highlighting the utility of ultrasound in the assessment of nerve pathology in these patient groups. John Wiley & Sons, Inc. 2022-02-23 2022-05 /pmc/articles/PMC9305967/ /pubmed/35119701 http://dx.doi.org/10.1002/mus.27513 Text en © 2022 The Authors. Muscle & Nerve published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Clinical Research Short Reports Issar, Tushar Walker, Susan Arnold, Ria Poynten, Ann M. Endre, Zoltan H. Krishnan, Arun V. Peripheral nerve morphology and intraneural blood flow in chronic kidney disease with and without diabetes |
title | Peripheral nerve morphology and intraneural blood flow in chronic kidney disease with and without diabetes |
title_full | Peripheral nerve morphology and intraneural blood flow in chronic kidney disease with and without diabetes |
title_fullStr | Peripheral nerve morphology and intraneural blood flow in chronic kidney disease with and without diabetes |
title_full_unstemmed | Peripheral nerve morphology and intraneural blood flow in chronic kidney disease with and without diabetes |
title_short | Peripheral nerve morphology and intraneural blood flow in chronic kidney disease with and without diabetes |
title_sort | peripheral nerve morphology and intraneural blood flow in chronic kidney disease with and without diabetes |
topic | Clinical Research Short Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305967/ https://www.ncbi.nlm.nih.gov/pubmed/35119701 http://dx.doi.org/10.1002/mus.27513 |
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