Phase II Study of ONC201 in Neuroendocrine Tumors including Pheochromocytoma-Paraganglioma and Desmoplastic Small Round Cell Tumor

PURPOSE: Tumor dopamine-like DRD2 receptor expression is higher in pheochromocytoma-paraganglioma (PC-PG) compared with other cancers. ONC201 is a bitopic DRD2 antagonist with preclinical ONC201 activity in desmoplastic small round cell tumor (DSRCT). PATIENTS AND METHODS: Patients (N = 30) with neu...

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Detalles Bibliográficos
Autores principales: Anderson, Peter M., Trucco, Matteo M., Tarapore, Rohinton S., Zahler, Stacey, Thomas, Stefanie, Gortz, Janette, Mian, Omar, Stoignew, Martin, Prabhu, Varun, Morrow, Sara, Allen, Joshua E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Clinical Trials: Targeted Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306280/
https://www.ncbi.nlm.nih.gov/pubmed/35022321
http://dx.doi.org/10.1158/1078-0432.CCR-21-4030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306280/
https://www.ncbi.nlm.nih.gov/pubmed/35022321
http://dx.doi.org/10.1158/1078-0432.CCR-21-4030

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