Double Trouble: Whole-Genome Doubling Distinguishes Early from Late Ovarian Cancer

Dramatic differences in outcome between early- and late-stage high-grade serous ovarian cancer (HGSC) suggest perhaps distinct genetic origins due to differences in exposures to mutational processes. Evidence to support this hypothesis was recently reported by comparative analysis of copy-number sig...

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Detalles Bibliográficos
Autores principales: Yang, Shih Yu Cindy, Pugh, Trevor J., Oza, Amit M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
CCR Translations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306310/
https://www.ncbi.nlm.nih.gov/pubmed/35476137
http://dx.doi.org/10.1158/1078-0432.CCR-22-0336
Descripción
Sumario:Dramatic differences in outcome between early- and late-stage high-grade serous ovarian cancer (HGSC) suggest perhaps distinct genetic origins due to differences in exposures to mutational processes. Evidence to support this hypothesis was recently reported by comparative analysis of copy-number signatures between early- and late-stage HGSCs. See related article by Cheng et al., p. 2911

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