Double Trouble: Whole-Genome Doubling Distinguishes Early from Late Ovarian Cancer

Dramatic differences in outcome between early- and late-stage high-grade serous ovarian cancer (HGSC) suggest perhaps distinct genetic origins due to differences in exposures to mutational processes. Evidence to support this hypothesis was recently reported by comparative analysis of copy-number sig...

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Detalles Bibliográficos
Autores principales: Yang, Shih Yu Cindy, Pugh, Trevor J., Oza, Amit M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
CCR Translations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306310/
https://www.ncbi.nlm.nih.gov/pubmed/35476137
http://dx.doi.org/10.1158/1078-0432.CCR-22-0336
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author Yang, Shih Yu Cindy
Pugh, Trevor J.
Oza, Amit M.
author_facet Yang, Shih Yu Cindy
Pugh, Trevor J.
Oza, Amit M.
author_sort Yang, Shih Yu Cindy
collection PubMed
description Dramatic differences in outcome between early- and late-stage high-grade serous ovarian cancer (HGSC) suggest perhaps distinct genetic origins due to differences in exposures to mutational processes. Evidence to support this hypothesis was recently reported by comparative analysis of copy-number signatures between early- and late-stage HGSCs. See related article by Cheng et al., p. 2911
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spelling pubmed-93063102023-01-05 Double Trouble: Whole-Genome Doubling Distinguishes Early from Late Ovarian Cancer Yang, Shih Yu Cindy Pugh, Trevor J. Oza, Amit M. Clin Cancer Res CCR Translations Dramatic differences in outcome between early- and late-stage high-grade serous ovarian cancer (HGSC) suggest perhaps distinct genetic origins due to differences in exposures to mutational processes. Evidence to support this hypothesis was recently reported by comparative analysis of copy-number signatures between early- and late-stage HGSCs. See related article by Cheng et al., p. 2911 American Association for Cancer Research 2022-07-01 2022-04-27 /pmc/articles/PMC9306310/ /pubmed/35476137 http://dx.doi.org/10.1158/1078-0432.CCR-22-0336 Text en ©2022 The Authors; Published by the American Association for Cancer Research https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.
spellingShingle CCR Translations
Yang, Shih Yu Cindy
Pugh, Trevor J.
Oza, Amit M.
Double Trouble: Whole-Genome Doubling Distinguishes Early from Late Ovarian Cancer
title Double Trouble: Whole-Genome Doubling Distinguishes Early from Late Ovarian Cancer
title_full Double Trouble: Whole-Genome Doubling Distinguishes Early from Late Ovarian Cancer
title_fullStr Double Trouble: Whole-Genome Doubling Distinguishes Early from Late Ovarian Cancer
title_full_unstemmed Double Trouble: Whole-Genome Doubling Distinguishes Early from Late Ovarian Cancer
title_short Double Trouble: Whole-Genome Doubling Distinguishes Early from Late Ovarian Cancer
title_sort double trouble: whole-genome doubling distinguishes early from late ovarian cancer
topic CCR Translations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306310/
https://www.ncbi.nlm.nih.gov/pubmed/35476137
http://dx.doi.org/10.1158/1078-0432.CCR-22-0336
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