SNP-to-gene linking strategies reveal contributions of enhancer-related and candidate master-regulator genes to autoimmune disease

We assess contributions to autoimmune disease of genes whose regulation is driven by enhancer regions (enhancer-related) and genes that regulate other genes in trans (candidate master-regulator). We link these genes to SNPs using several SNP-to-gene (S2G) strategies and apply heritability analyses t...

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Detalles Bibliográficos
Autores principales: Dey, Kushal K., Gazal, Steven, van de Geijn, Bryce, Kim, Samuel Sungil, Nasser, Joseph, Engreitz, Jesse M., Price, Alkes L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306342/
https://www.ncbi.nlm.nih.gov/pubmed/35873673
http://dx.doi.org/10.1016/j.xgen.2022.100145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306342/
https://www.ncbi.nlm.nih.gov/pubmed/35873673
http://dx.doi.org/10.1016/j.xgen.2022.100145

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