The TAZ-CAMTA1 Fusion Protein Promotes Tumorigenesis via Connective Tissue Growth Factor and Ras–MAPK Signaling in Epithelioid Hemangioendothelioma

PURPOSE: A consistent genetic alteration in vascular cancer epithelioid hemangioendothelioma (EHE) is the t(1;3)(p36;q25) chromosomal translocation, which generates a WWTR1(TAZ)-CAMTA1 (TC) fusion gene. TC is a transcriptional coactivator that drives EHE. Here, we aimed to identify the TC transcript...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Shuang, Kanai, Ryan, Pobbati, Ajaybabu V., Li, Shuo, Che, Kepeng, Seavey, Caleb N., Hallett, Andrea, Burtscher, Ashley, Lamar, John M., Rubin, Brian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306355/
https://www.ncbi.nlm.nih.gov/pubmed/35443056
http://dx.doi.org/10.1158/1078-0432.CCR-22-0421

Ejemplares similares

Ejemplares similares