Cargando…

DNA-PKcs: A Targetable Protumorigenic Protein Kinase

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a pleiotropic protein kinase that plays critical roles in cellular processes fundamental to cancer. DNA-PKcs expression and activity are frequently deregulated in multiple hematologic and solid tumors and have been tightly linked to poor o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dylgjeri, Emanuela, Knudsen, Karen E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306356/ https://www.ncbi.nlm.nih.gov/pubmed/34893509 http://dx.doi.org/10.1158/0008-5472.CAN-21-1756

Ejemplares similares

Identification of DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs) as a Novel Target of Bisphenol A
por: Ito, Yuki, et al.
Publicado: (2012)

ATM, ATR and DNA-PKcs kinases—the lessons from the mouse models: inhibition ≠ deletion
por: Menolfi, Demis, et al.
Publicado: (2020)

A tale of three PKCs: Epsilon emerges as a driver of pre-neoplastic phenotypes
por: Knudsen, Karen E.
Publicado: (2011)

The roles of atypical protein kinase Cs (aPKCs) in the nervous system: targets for neuroregeneration?
por: Chau, Dennis Dik-Long, et al.
Publicado: (2020)

Targeting DNA-PKcs and telomerase in brain tumour cells
por: Gurung, Resham Lal, et al.
Publicado: (2014)

DNA-PKcs PARylation regulates DNA-PK kinase activity in the DNA damage response
por: Han, Yang, et al.
Publicado: (2019)

Assessment of DNA-PKcs kinase activity by quantum dot–based microarray
por: Lafont, Florian, et al.
Publicado: (2018)

DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs): Beyond the DNA Double-Strand Break Repair
por: Lee, Ye-Rim, et al.
Publicado: (2023)

Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs
por: Liang, Shikang, et al.
Publicado: (2022)

Beyond DNA Repair: DNA-PKcs in Tumor Metastasis, Metabolism and Immunity
por: Yang, Haitang, et al.
Publicado: (2020)

KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms
por: Chen, Min-Bin, et al.
Publicado: (2016)

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives chronic kidney disease progression in male mice
por: Yang, Yunwen, et al.
Publicado: (2023)

Bone Morphogenetic Protein 13 Has Protumorigenic Effects on Hepatocellular Carcinoma Cells In Vitro
por: Kersten, Vanessa, et al.
Publicado: (2023)

DNA-PKcs participated in hypoxic pulmonary hypertension
por: Liu, Ying-ying, et al.
Publicado: (2022)

Unraveling the roles of WRN and DNA-PKcs at telomeres
por: Beattie, Tara L., et al.
Publicado: (2010)

Lost in the bloom: DNA-PKcs in green plants
por: Kumar, Koppolu Raja Rajesh
Publicado: (2023)

Obesity Does Not Exacerbate the Protumorigenic Systemic Environment in Sarcoma Subjects
por: Buchta, Claire M., et al.
Publicado: (2017)

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) contributes to incorporation of histone variant H2A.Z into nucleosomes
por: Wang, Ling-Yao, et al.
Publicado: (2019)

DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells
por: Waldrip, Zachary J., et al.
Publicado: (2021)

NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair
por: Munnur, Deeksha, et al.
Publicado: (2019)

Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes
por: Fordyce, Colleen A, et al.
Publicado: (2012)

Targeting DNA-PKcs and ATM with miR-101 Sensitizes Tumors to Radiation
por: Yan, Dan, et al.
Publicado: (2010)

DNA structure-specific priming of ATR activation by DNA-PKcs
por: Vidal-Eychenié, Sophie, et al.
Publicado: (2013)

Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression: A Double-Edged Sword
por: Li, Howard, et al.
Publicado: (2012)

Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis
por: Douglas, Pauline, et al.
Publicado: (2014)

ANKFN1 plays both protumorigenic and metastatic roles in hepatocellular carcinoma
por: Wang, Yanyan, et al.
Publicado: (2022)

DNA-PKcs: A Multi-Faceted Player in DNA Damage Response
por: Yue, Xiaoqiao, et al.
Publicado: (2020)

MDSCs are involved in the protumorigenic potentials of GM-CSF in colitis-associated cancer
por: Ma, Ning, et al.
Publicado: (2017)

Lipid accumulation in macrophages confers protumorigenic polarization and immunity in gastric cancer
por: Luo, Qin, et al.
Publicado: (2020)

Cancer‐associated V‐ATPase induces delayed apoptosis of protumorigenic neutrophils
por: Ibrahim, Safaa A., et al.
Publicado: (2020)

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives angiotensin II-induced vascular remodeling through regulating mitochondrial fragmentation
por: Wang, Litao, et al.
Publicado: (2023)

Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ
por: Chen, Siyu, et al.
Publicado: (2023)

LINC-PINT impedes DNA repair and enhances radiotherapeutic response by targeting DNA-PKcs in nasopharyngeal cancer
por: Wang, You-hong, et al.
Publicado: (2021)

Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells
por: Jiang, N, et al.
Publicado: (2013)

Structural analysis of the basal state of the Artemis:DNA-PKcs complex
por: Watanabe, Go, et al.
Publicado: (2022)

MINDIN Exerts Protumorigenic Actions on Primary Prostate Tumors via Downregulation of the Scaffold Protein NHERF-1
por: Álvarez-Carrión, Luis, et al.
Publicado: (2021)

Enhancing CRISPR deletion via pharmacological delay of DNA-PKcs
por: Bosch-Guiteras, Núria, et al.
Publicado: (2021)

Dietary Fat-Accelerating Leptin Signaling Promotes Protumorigenic Gastric Environment in Mice
por: Arita, Seiya, et al.
Publicado: (2019)

Shifting the Soil: Metformin Treatment Decreases the Protumorigenic Tumor Microenvironment in Epithelial Ovarian Cancer
por: Taylor, Sarah E., et al.
Publicado: (2022)

The leucine rich region of DNA-PKcs contributes to its innate DNA affinity
por: Gupta, Shikha, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_ihk44v4n9t3uk21kocqfao59eh