Thrombin in complex with dabigatran can still interact with PAR‐1 via exosite‐I and instigate loss of vascular integrity

BACKGROUND: Atrial fibrillation (AF) can lead to the loss of microvascular integrity thereby enhancing AF progression. Mechanistically, the pro‐coagulant state that drives the risk of stroke in patients with AF may also play a causal role in microvascular loss. Direct oral anticoagulants (DOACs), th...

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Detalles Bibliográficos
Autores principales: Dólleman, Sophie C., Agten, Stijn M., Spronk, Henri M. H., Hackeng, Tilman M., Bos, Mettine H. A., Versteeg, Henri H., van Zonneveld, Anton Jan, de Boer, Hetty C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
VASCULAR BIOLOGY
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306515/
https://www.ncbi.nlm.nih.gov/pubmed/35037739
http://dx.doi.org/10.1111/jth.15642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306515/
https://www.ncbi.nlm.nih.gov/pubmed/35037739
http://dx.doi.org/10.1111/jth.15642

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