Cargando…

Design, realization, and characterization of a novel diamond detector prototype for FLASH radiotherapy dosimetry

PURPOSE: FLASH radiotherapy (RT) is an emerging technique in which beams with ultra‐high dose rates (UH‐DR) and dose per pulse (UH‐DPP) are used. Commercially available active real‐time dosimeters have been shown to be unsuitable in such conditions, due to severe response nonlinearities. In the pres...

Descripción completa

Detalles Bibliográficos
Autores principales: Marinelli, Marco, Felici, Giuseppe, Galante, Federica, Gasparini, Alessia, Giuliano, Lucia, Heinrich, Sophie, Pacitti, Matteo, Prestopino, Giuseppe, Vanreusel, Verdi, Verellen, Dirk, Verona, Claudio, Verona Rinati, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306529/
https://www.ncbi.nlm.nih.gov/pubmed/35064594
http://dx.doi.org/10.1002/mp.15473
_version_ 1784752558795915264
author Marinelli, Marco
Felici, Giuseppe
Galante, Federica
Gasparini, Alessia
Giuliano, Lucia
Heinrich, Sophie
Pacitti, Matteo
Prestopino, Giuseppe
Vanreusel, Verdi
Verellen, Dirk
Verona, Claudio
Verona Rinati, Gianluca
author_facet Marinelli, Marco
Felici, Giuseppe
Galante, Federica
Gasparini, Alessia
Giuliano, Lucia
Heinrich, Sophie
Pacitti, Matteo
Prestopino, Giuseppe
Vanreusel, Verdi
Verellen, Dirk
Verona, Claudio
Verona Rinati, Gianluca
author_sort Marinelli, Marco
collection PubMed
description PURPOSE: FLASH radiotherapy (RT) is an emerging technique in which beams with ultra‐high dose rates (UH‐DR) and dose per pulse (UH‐DPP) are used. Commercially available active real‐time dosimeters have been shown to be unsuitable in such conditions, due to severe response nonlinearities. In the present study, a novel diamond‐based Schottky diode detector was specifically designed and realized to match the stringent requirements of FLASH‐RT. METHODS: A systematic investigation of the main features affecting the diamond response in UH‐DPP conditions was carried out. Several diamond Schottky diode detector prototypes with different layouts were produced at Rome Tor Vergata University in cooperation with PTW‐Freiburg. Such devices were tested under electron UH‐DPP beams. The linearity of the prototypes was investigated up to DPPs of about 26 Gy/pulse and dose rates of approximately 1 kGy/s. In addition, percentage depth dose (PDD) measurements were performed in different irradiation conditions. Radiochromic films were used for reference dosimetry. RESULTS: The response linearity of the diamond prototypes was shown to be strongly affected by the size of their active volume as well as by their series resistance. By properly tuning the design layout, the detector response was found to be linear up to at least 20 Gy/pulse, well into the UH‐DPP range conditions. PDD measurements were performed by three different linac applicators, characterized by DPP values at the point of maximum dose of 3.5, 17.2, and 20.6 Gy/pulse, respectively. The very good superimposition of three curves confirmed the diamond response linearity. It is worth mentioning that UH‐DPP irradiation conditions may lead to instantaneous detector currents as high as several mA, thus possibly exceeding the electrometer specifications. This issue was properly addressed in the case of the PTW UNIDOS electrometers. CONCLUSIONS: The results of the present study clearly demonstrate the feasibility of a diamond detector for FLASH‐RT applications.
format Online
Article
Text
id pubmed-9306529
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-93065292022-07-28 Design, realization, and characterization of a novel diamond detector prototype for FLASH radiotherapy dosimetry Marinelli, Marco Felici, Giuseppe Galante, Federica Gasparini, Alessia Giuliano, Lucia Heinrich, Sophie Pacitti, Matteo Prestopino, Giuseppe Vanreusel, Verdi Verellen, Dirk Verona, Claudio Verona Rinati, Gianluca Med Phys COMPUTATIONAL AND EXPERIMENTAL DOSIMETRY PURPOSE: FLASH radiotherapy (RT) is an emerging technique in which beams with ultra‐high dose rates (UH‐DR) and dose per pulse (UH‐DPP) are used. Commercially available active real‐time dosimeters have been shown to be unsuitable in such conditions, due to severe response nonlinearities. In the present study, a novel diamond‐based Schottky diode detector was specifically designed and realized to match the stringent requirements of FLASH‐RT. METHODS: A systematic investigation of the main features affecting the diamond response in UH‐DPP conditions was carried out. Several diamond Schottky diode detector prototypes with different layouts were produced at Rome Tor Vergata University in cooperation with PTW‐Freiburg. Such devices were tested under electron UH‐DPP beams. The linearity of the prototypes was investigated up to DPPs of about 26 Gy/pulse and dose rates of approximately 1 kGy/s. In addition, percentage depth dose (PDD) measurements were performed in different irradiation conditions. Radiochromic films were used for reference dosimetry. RESULTS: The response linearity of the diamond prototypes was shown to be strongly affected by the size of their active volume as well as by their series resistance. By properly tuning the design layout, the detector response was found to be linear up to at least 20 Gy/pulse, well into the UH‐DPP range conditions. PDD measurements were performed by three different linac applicators, characterized by DPP values at the point of maximum dose of 3.5, 17.2, and 20.6 Gy/pulse, respectively. The very good superimposition of three curves confirmed the diamond response linearity. It is worth mentioning that UH‐DPP irradiation conditions may lead to instantaneous detector currents as high as several mA, thus possibly exceeding the electrometer specifications. This issue was properly addressed in the case of the PTW UNIDOS electrometers. CONCLUSIONS: The results of the present study clearly demonstrate the feasibility of a diamond detector for FLASH‐RT applications. John Wiley and Sons Inc. 2022-01-31 2022-03 /pmc/articles/PMC9306529/ /pubmed/35064594 http://dx.doi.org/10.1002/mp.15473 Text en © 2022 The Authors. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle COMPUTATIONAL AND EXPERIMENTAL DOSIMETRY
Marinelli, Marco
Felici, Giuseppe
Galante, Federica
Gasparini, Alessia
Giuliano, Lucia
Heinrich, Sophie
Pacitti, Matteo
Prestopino, Giuseppe
Vanreusel, Verdi
Verellen, Dirk
Verona, Claudio
Verona Rinati, Gianluca
Design, realization, and characterization of a novel diamond detector prototype for FLASH radiotherapy dosimetry
title Design, realization, and characterization of a novel diamond detector prototype for FLASH radiotherapy dosimetry
title_full Design, realization, and characterization of a novel diamond detector prototype for FLASH radiotherapy dosimetry
title_fullStr Design, realization, and characterization of a novel diamond detector prototype for FLASH radiotherapy dosimetry
title_full_unstemmed Design, realization, and characterization of a novel diamond detector prototype for FLASH radiotherapy dosimetry
title_short Design, realization, and characterization of a novel diamond detector prototype for FLASH radiotherapy dosimetry
title_sort design, realization, and characterization of a novel diamond detector prototype for flash radiotherapy dosimetry
topic COMPUTATIONAL AND EXPERIMENTAL DOSIMETRY
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306529/
https://www.ncbi.nlm.nih.gov/pubmed/35064594
http://dx.doi.org/10.1002/mp.15473
work_keys_str_mv AT marinellimarco designrealizationandcharacterizationofanoveldiamonddetectorprototypeforflashradiotherapydosimetry
AT felicigiuseppe designrealizationandcharacterizationofanoveldiamonddetectorprototypeforflashradiotherapydosimetry
AT galantefederica designrealizationandcharacterizationofanoveldiamonddetectorprototypeforflashradiotherapydosimetry
AT gasparinialessia designrealizationandcharacterizationofanoveldiamonddetectorprototypeforflashradiotherapydosimetry
AT giulianolucia designrealizationandcharacterizationofanoveldiamonddetectorprototypeforflashradiotherapydosimetry
AT heinrichsophie designrealizationandcharacterizationofanoveldiamonddetectorprototypeforflashradiotherapydosimetry
AT pacittimatteo designrealizationandcharacterizationofanoveldiamonddetectorprototypeforflashradiotherapydosimetry
AT prestopinogiuseppe designrealizationandcharacterizationofanoveldiamonddetectorprototypeforflashradiotherapydosimetry
AT vanreuselverdi designrealizationandcharacterizationofanoveldiamonddetectorprototypeforflashradiotherapydosimetry
AT verellendirk designrealizationandcharacterizationofanoveldiamonddetectorprototypeforflashradiotherapydosimetry
AT veronaclaudio designrealizationandcharacterizationofanoveldiamonddetectorprototypeforflashradiotherapydosimetry
AT veronarinatigianluca designrealizationandcharacterizationofanoveldiamonddetectorprototypeforflashradiotherapydosimetry