Structure‐guided stabilization of pathogen‐derived peptide‐HLA‐E complexes using non‐natural amino acids conserves native TCR recognition

The nonpolymorphic class Ib molecule, HLA‐E, primarily presents peptides from HLA class Ia leader peptides, providing an inhibitory signal to NK cells via CD94/NKG2 interactions. Although peptides of pathogenic origin can also be presented by HLA‐E to T cells, the molecular basis underpinning their...

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Detalles Bibliográficos
Autores principales: Barber, Claire, De Souza, Victoria Arena, Paterson, Rachel L., Martin‐Urdiroz, Magdalena, Mulakkal, Nitha Charles, Srikannathasan, Velupillai, Connolly, Mary, Phillips, Gwilym, Foong‐Leong, Tein, Pengelly, Robert, Karuppiah, Vijaykumar, Grant, Tressan, Dembek, Marcin, Verma, Anil, Gibbs‐Howe, Dawn, Blicher, Thomas H., Knox, Andrew, Robinson, Ross A., Cole, David K., Leonard, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Molecular immunology and signaling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306587/
https://www.ncbi.nlm.nih.gov/pubmed/35108401
http://dx.doi.org/10.1002/eji.202149745

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