Loss of bile salt export pump aggravates lipopolysaccharide‐induced liver injury in mice due to impaired hepatic endotoxin clearance

BACKGROUND AND AIMS: Lipopolysaccharide (LPS) clearance is delayed in cholestatic liver diseases. While compromised clearance by Kupffer cells (KCs) is involved, the role of LPS uptake into hepatocytes and canalicular excretion remains unclear. APPROACH AND RESULTS: Wild‐type (WT) and bile salt expo...

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Detalles Bibliográficos
Autores principales: Remetic, Jelena, Ghallab, Ahmed, Hobloss, Zaynab, Brackhagen, Lisa, Hassan, Reham, Myllys, Maiju, Radun, Richard, Mlitz, Veronika, Zhu, Ci, Baumgartner, Maximilian, Schrottmaier, Waltraud C., Mussbacher, Marion, Timelthaler, Gerald, Scharnagl, Hubert, Stojakovic, Tatjana, Assinger, Alice, Fuchs, Claudia D., Hengstler, Jan G., Trauner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306629/
https://www.ncbi.nlm.nih.gov/pubmed/34927748
http://dx.doi.org/10.1002/hep.32289

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