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The impact of birthweight on subsequent phenotype of type 2 diabetes in later life

AIMS: It is well established that low birthweight is associated with subsequent risk of type 2 diabetes (T2DM). The aim of our study was to use a large birth cohort linked to a national diabetes registry to investigate how birthweight impacts the phenotype at diagnosis of T2DM and the subsequent rat...

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Autores principales: Paulina, Christian, Donnelly, Louise A., Pearson, Ewan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306733/
https://www.ncbi.nlm.nih.gov/pubmed/35030268
http://dx.doi.org/10.1111/dme.14792
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author Paulina, Christian
Donnelly, Louise A.
Pearson, Ewan R.
author_facet Paulina, Christian
Donnelly, Louise A.
Pearson, Ewan R.
author_sort Paulina, Christian
collection PubMed
description AIMS: It is well established that low birthweight is associated with subsequent risk of type 2 diabetes (T2DM). The aim of our study was to use a large birth cohort linked to a national diabetes registry to investigate how birthweight impacts the phenotype at diagnosis of T2DM and the subsequent rate of glycaemic deterioration. METHODS: We linked the Walker Birth Cohort (48,000 births, 1952–1966, Tayside, Scotland) to the national diabetes registry in Scotland (SCI‐Diabetes). Birthweight was adjusted for gestational age. Simple linear regression was performed to assess the impact of the adjusted birthweight on the diabetes phenotype at diagnosis. This was then built up into a multiple regression model to allow for the adjustment of confounding variables. A cox proportional hazards model was then used to evaluate the impact of birthweight on diabetes progression. RESULTS: Lower birthweights were associated with a 293 day younger age of diagnosis of T2DM per 1 kg reduction in birthweight, p = 0.005; and a 1.29 kg/m(2) lower BMI at diagnosis per 1 kg reduction in birthweight, p < 0.001. There was no significant association of birthweight on diabetes progression. CONCLUSION: For the first time, we have shown that a lower birthweight is associated with younger onset of T2DM, with those with lower birthweight also being slimmer at diagnosis. These results suggest that lower birthweight impacts on T2DM phenotype via reduced beta‐cell function rather than insulin resistance.
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spelling pubmed-93067332022-07-28 The impact of birthweight on subsequent phenotype of type 2 diabetes in later life Paulina, Christian Donnelly, Louise A. Pearson, Ewan R. Diabet Med Research: Epidemiology AIMS: It is well established that low birthweight is associated with subsequent risk of type 2 diabetes (T2DM). The aim of our study was to use a large birth cohort linked to a national diabetes registry to investigate how birthweight impacts the phenotype at diagnosis of T2DM and the subsequent rate of glycaemic deterioration. METHODS: We linked the Walker Birth Cohort (48,000 births, 1952–1966, Tayside, Scotland) to the national diabetes registry in Scotland (SCI‐Diabetes). Birthweight was adjusted for gestational age. Simple linear regression was performed to assess the impact of the adjusted birthweight on the diabetes phenotype at diagnosis. This was then built up into a multiple regression model to allow for the adjustment of confounding variables. A cox proportional hazards model was then used to evaluate the impact of birthweight on diabetes progression. RESULTS: Lower birthweights were associated with a 293 day younger age of diagnosis of T2DM per 1 kg reduction in birthweight, p = 0.005; and a 1.29 kg/m(2) lower BMI at diagnosis per 1 kg reduction in birthweight, p < 0.001. There was no significant association of birthweight on diabetes progression. CONCLUSION: For the first time, we have shown that a lower birthweight is associated with younger onset of T2DM, with those with lower birthweight also being slimmer at diagnosis. These results suggest that lower birthweight impacts on T2DM phenotype via reduced beta‐cell function rather than insulin resistance. John Wiley and Sons Inc. 2022-01-22 2022-07 /pmc/articles/PMC9306733/ /pubmed/35030268 http://dx.doi.org/10.1111/dme.14792 Text en © 2022 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research: Epidemiology
Paulina, Christian
Donnelly, Louise A.
Pearson, Ewan R.
The impact of birthweight on subsequent phenotype of type 2 diabetes in later life
title The impact of birthweight on subsequent phenotype of type 2 diabetes in later life
title_full The impact of birthweight on subsequent phenotype of type 2 diabetes in later life
title_fullStr The impact of birthweight on subsequent phenotype of type 2 diabetes in later life
title_full_unstemmed The impact of birthweight on subsequent phenotype of type 2 diabetes in later life
title_short The impact of birthweight on subsequent phenotype of type 2 diabetes in later life
title_sort impact of birthweight on subsequent phenotype of type 2 diabetes in later life
topic Research: Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306733/
https://www.ncbi.nlm.nih.gov/pubmed/35030268
http://dx.doi.org/10.1111/dme.14792
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