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Women with HIV transitioning through menopause: Insights from the Swiss HIV Cohort Study (SHCS)

OBJECTIVES: We aimed to assess prevalence and age at menopause, identify factors associated with early menopause and explore the provision and utilization of healthcare in women living with HIV in Switzerland. METHODS: This was a retrospective Swiss HIV Cohort Study analysis from January 2010 to Dec...

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Autores principales: Hachfeld, Anna, Atkinson, Andrew, Stute, Petra, Calmy, Alexandra, Tarr, Philip E., Darling, Katharine, Babouee Flury, Baharak, Polli, Christian, Sultan‐Beyer, Leila, Abela, Irene A., Aebi‐Popp, Karoline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306735/
https://www.ncbi.nlm.nih.gov/pubmed/35194949
http://dx.doi.org/10.1111/hiv.13255
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author Hachfeld, Anna
Atkinson, Andrew
Stute, Petra
Calmy, Alexandra
Tarr, Philip E.
Darling, Katharine
Babouee Flury, Baharak
Polli, Christian
Sultan‐Beyer, Leila
Abela, Irene A.
Aebi‐Popp, Karoline
author_facet Hachfeld, Anna
Atkinson, Andrew
Stute, Petra
Calmy, Alexandra
Tarr, Philip E.
Darling, Katharine
Babouee Flury, Baharak
Polli, Christian
Sultan‐Beyer, Leila
Abela, Irene A.
Aebi‐Popp, Karoline
author_sort Hachfeld, Anna
collection PubMed
description OBJECTIVES: We aimed to assess prevalence and age at menopause, identify factors associated with early menopause and explore the provision and utilization of healthcare in women living with HIV in Switzerland. METHODS: This was a retrospective Swiss HIV Cohort Study analysis from January 2010 to December 2018. Descriptive statistics to characterise the population and menopause onset. Logistic regression analysis to identify risk factors for early menopause. RESULTS: Of all women in the SHCS, the proportion of postmenopausal women tripled from 11.5% (n = 274) in 2010 to 36.1% (n = 961) in 2018. The median age at menopause was 50 years. Early menopause (< 45 years) occurred in 115 (10.2%) women and premature ovarian insufficiency (POI) (< 40 years) in 23 (2%) women. Early menopause was associated with black ethnicity (52.2% vs. 21.6%, p < 0.001), but not with HIV acquisition mode, CDC stage, viral suppression, CD4 cell count, hepatitis C, smoking or active drug use. While 92% of the postmenopausal women underwent a gynaecological examination during the 36 months before menopause documentation, only 27% received a bone mineral density measurement within 36 months after the last bleed and 11% were on hormone replacement therapy at the time of menopause documentation. CONCLUSIONS: The median age of women living with HIV at menopause is around 2 years lower than that reported for HIV‐negative women in Switzerland. HIV care providers need to adapt their services to the requirements of the increasing number of women living with HIV transitioning through menopause. They should be able to recognize menopause‐associated symptoms and improve access to bone mineral density measurement as well as hormone replacement therapy.
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spelling pubmed-93067352022-07-28 Women with HIV transitioning through menopause: Insights from the Swiss HIV Cohort Study (SHCS) Hachfeld, Anna Atkinson, Andrew Stute, Petra Calmy, Alexandra Tarr, Philip E. Darling, Katharine Babouee Flury, Baharak Polli, Christian Sultan‐Beyer, Leila Abela, Irene A. Aebi‐Popp, Karoline HIV Med Original Research OBJECTIVES: We aimed to assess prevalence and age at menopause, identify factors associated with early menopause and explore the provision and utilization of healthcare in women living with HIV in Switzerland. METHODS: This was a retrospective Swiss HIV Cohort Study analysis from January 2010 to December 2018. Descriptive statistics to characterise the population and menopause onset. Logistic regression analysis to identify risk factors for early menopause. RESULTS: Of all women in the SHCS, the proportion of postmenopausal women tripled from 11.5% (n = 274) in 2010 to 36.1% (n = 961) in 2018. The median age at menopause was 50 years. Early menopause (< 45 years) occurred in 115 (10.2%) women and premature ovarian insufficiency (POI) (< 40 years) in 23 (2%) women. Early menopause was associated with black ethnicity (52.2% vs. 21.6%, p < 0.001), but not with HIV acquisition mode, CDC stage, viral suppression, CD4 cell count, hepatitis C, smoking or active drug use. While 92% of the postmenopausal women underwent a gynaecological examination during the 36 months before menopause documentation, only 27% received a bone mineral density measurement within 36 months after the last bleed and 11% were on hormone replacement therapy at the time of menopause documentation. CONCLUSIONS: The median age of women living with HIV at menopause is around 2 years lower than that reported for HIV‐negative women in Switzerland. HIV care providers need to adapt their services to the requirements of the increasing number of women living with HIV transitioning through menopause. They should be able to recognize menopause‐associated symptoms and improve access to bone mineral density measurement as well as hormone replacement therapy. John Wiley and Sons Inc. 2022-02-22 2022-04 /pmc/articles/PMC9306735/ /pubmed/35194949 http://dx.doi.org/10.1111/hiv.13255 Text en © 2022 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Hachfeld, Anna
Atkinson, Andrew
Stute, Petra
Calmy, Alexandra
Tarr, Philip E.
Darling, Katharine
Babouee Flury, Baharak
Polli, Christian
Sultan‐Beyer, Leila
Abela, Irene A.
Aebi‐Popp, Karoline
Women with HIV transitioning through menopause: Insights from the Swiss HIV Cohort Study (SHCS)
title Women with HIV transitioning through menopause: Insights from the Swiss HIV Cohort Study (SHCS)
title_full Women with HIV transitioning through menopause: Insights from the Swiss HIV Cohort Study (SHCS)
title_fullStr Women with HIV transitioning through menopause: Insights from the Swiss HIV Cohort Study (SHCS)
title_full_unstemmed Women with HIV transitioning through menopause: Insights from the Swiss HIV Cohort Study (SHCS)
title_short Women with HIV transitioning through menopause: Insights from the Swiss HIV Cohort Study (SHCS)
title_sort women with hiv transitioning through menopause: insights from the swiss hiv cohort study (shcs)
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306735/
https://www.ncbi.nlm.nih.gov/pubmed/35194949
http://dx.doi.org/10.1111/hiv.13255
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