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Neuroimaging features of angiocentric glioma: A case series and systematic review
BACKGROUND AND PURPOSE: Angiocentric gliomas (AGs) are epileptogenic low‐grade gliomas in young patients. We aimed to investigate the MRI findings of AGs and systematically review previous publications and three new cases. METHODS: We searched PubMed, Elsevier's abstract and citation database,...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306893/ https://www.ncbi.nlm.nih.gov/pubmed/35201652 http://dx.doi.org/10.1111/jon.12983 |
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author | Kurokawa, Ryo Baba, Akira Emile, Pinarbasi Kurokawa, Mariko Ota, Yoshiaki Kim, John Capizzano, Aristides Srinivasan, Ashok Moritani, Toshio |
author_facet | Kurokawa, Ryo Baba, Akira Emile, Pinarbasi Kurokawa, Mariko Ota, Yoshiaki Kim, John Capizzano, Aristides Srinivasan, Ashok Moritani, Toshio |
author_sort | Kurokawa, Ryo |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Angiocentric gliomas (AGs) are epileptogenic low‐grade gliomas in young patients. We aimed to investigate the MRI findings of AGs and systematically review previous publications and three new cases. METHODS: We searched PubMed, Elsevier's abstract and citation database, and Embase databases and included 50 patients with pathologically proven AGs with analyzable preoperative MRI including 3 patients from our institution and 47 patients from 38 publications (median age, 13 years [range, 2‐83 years]; 35 men). Two board‐certified radiologists reviewed all images. The relationships between seizure/epilepsy history and MRI findings were statistically analyzed. Moreover, clinical and imaging differences were evaluated between supratentorial and brainstem AGs. RESULTS: Intratumoral T1‐weighted high‐intensity areas, stalk‐like signs, and regional brain parenchymal atrophy were observed in 23 out of 50 (46.0%), 10 out of 50 (20.0%), and 14 out of 50 (28.0%) patients, respectively. Intratumoral T1‐weighted high‐intensity areas were observed significantly more frequently in patients with stalk‐like signs (positive, 9/10 vs. negative, 14/40, p = .0031) and regional atrophy (13/14 vs. 10/36, p = .0001). There were significant relationships between the length of seizure/epilepsy history and presence of intratumoral T1‐weighted high‐intensity area (median 3 years vs. 0.5 years, p = .0021), stalk‐like sign (13.5 vs. 1 year, p < .0001), and regional atrophy (14 vs. 0.5 years, p < .0001). Patients with brainstem AGs (n = 7) did not have a seizure/epilepsy history and were significantly younger than those with supratentorial AGs (median, 5 vs. 13 years, p < .0001, respectively). CONCLUSIONS: Intratumoral T1‐weighted high‐intensity areas, stalk‐like signs, and regional brain atrophy were frequent imaging features in AG. We also found that affected age was different between supratentorial and brainstem AGs. |
format | Online Article Text |
id | pubmed-9306893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93068932022-07-28 Neuroimaging features of angiocentric glioma: A case series and systematic review Kurokawa, Ryo Baba, Akira Emile, Pinarbasi Kurokawa, Mariko Ota, Yoshiaki Kim, John Capizzano, Aristides Srinivasan, Ashok Moritani, Toshio J Neuroimaging Review Articles BACKGROUND AND PURPOSE: Angiocentric gliomas (AGs) are epileptogenic low‐grade gliomas in young patients. We aimed to investigate the MRI findings of AGs and systematically review previous publications and three new cases. METHODS: We searched PubMed, Elsevier's abstract and citation database, and Embase databases and included 50 patients with pathologically proven AGs with analyzable preoperative MRI including 3 patients from our institution and 47 patients from 38 publications (median age, 13 years [range, 2‐83 years]; 35 men). Two board‐certified radiologists reviewed all images. The relationships between seizure/epilepsy history and MRI findings were statistically analyzed. Moreover, clinical and imaging differences were evaluated between supratentorial and brainstem AGs. RESULTS: Intratumoral T1‐weighted high‐intensity areas, stalk‐like signs, and regional brain parenchymal atrophy were observed in 23 out of 50 (46.0%), 10 out of 50 (20.0%), and 14 out of 50 (28.0%) patients, respectively. Intratumoral T1‐weighted high‐intensity areas were observed significantly more frequently in patients with stalk‐like signs (positive, 9/10 vs. negative, 14/40, p = .0031) and regional atrophy (13/14 vs. 10/36, p = .0001). There were significant relationships between the length of seizure/epilepsy history and presence of intratumoral T1‐weighted high‐intensity area (median 3 years vs. 0.5 years, p = .0021), stalk‐like sign (13.5 vs. 1 year, p < .0001), and regional atrophy (14 vs. 0.5 years, p < .0001). Patients with brainstem AGs (n = 7) did not have a seizure/epilepsy history and were significantly younger than those with supratentorial AGs (median, 5 vs. 13 years, p < .0001, respectively). CONCLUSIONS: Intratumoral T1‐weighted high‐intensity areas, stalk‐like signs, and regional brain atrophy were frequent imaging features in AG. We also found that affected age was different between supratentorial and brainstem AGs. John Wiley and Sons Inc. 2022-02-24 2022 /pmc/articles/PMC9306893/ /pubmed/35201652 http://dx.doi.org/10.1111/jon.12983 Text en © 2022 The Authors. Journal of Neuroimaging published by Wiley Periodicals LLC on behalf of American Society of Neuroimaging. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Articles Kurokawa, Ryo Baba, Akira Emile, Pinarbasi Kurokawa, Mariko Ota, Yoshiaki Kim, John Capizzano, Aristides Srinivasan, Ashok Moritani, Toshio Neuroimaging features of angiocentric glioma: A case series and systematic review |
title | Neuroimaging features of angiocentric glioma: A case series and systematic review |
title_full | Neuroimaging features of angiocentric glioma: A case series and systematic review |
title_fullStr | Neuroimaging features of angiocentric glioma: A case series and systematic review |
title_full_unstemmed | Neuroimaging features of angiocentric glioma: A case series and systematic review |
title_short | Neuroimaging features of angiocentric glioma: A case series and systematic review |
title_sort | neuroimaging features of angiocentric glioma: a case series and systematic review |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306893/ https://www.ncbi.nlm.nih.gov/pubmed/35201652 http://dx.doi.org/10.1111/jon.12983 |
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