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Neuroimaging features of angiocentric glioma: A case series and systematic review

BACKGROUND AND PURPOSE: Angiocentric gliomas (AGs) are epileptogenic low‐grade gliomas in young patients. We aimed to investigate the MRI findings of AGs and systematically review previous publications and three new cases. METHODS: We searched PubMed, Elsevier's abstract and citation database,...

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Autores principales: Kurokawa, Ryo, Baba, Akira, Emile, Pinarbasi, Kurokawa, Mariko, Ota, Yoshiaki, Kim, John, Capizzano, Aristides, Srinivasan, Ashok, Moritani, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306893/
https://www.ncbi.nlm.nih.gov/pubmed/35201652
http://dx.doi.org/10.1111/jon.12983
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author Kurokawa, Ryo
Baba, Akira
Emile, Pinarbasi
Kurokawa, Mariko
Ota, Yoshiaki
Kim, John
Capizzano, Aristides
Srinivasan, Ashok
Moritani, Toshio
author_facet Kurokawa, Ryo
Baba, Akira
Emile, Pinarbasi
Kurokawa, Mariko
Ota, Yoshiaki
Kim, John
Capizzano, Aristides
Srinivasan, Ashok
Moritani, Toshio
author_sort Kurokawa, Ryo
collection PubMed
description BACKGROUND AND PURPOSE: Angiocentric gliomas (AGs) are epileptogenic low‐grade gliomas in young patients. We aimed to investigate the MRI findings of AGs and systematically review previous publications and three new cases. METHODS: We searched PubMed, Elsevier's abstract and citation database, and Embase databases and included 50 patients with pathologically proven AGs with analyzable preoperative MRI including 3 patients from our institution and 47 patients from 38 publications (median age, 13 years [range, 2‐83 years]; 35 men). Two board‐certified radiologists reviewed all images. The relationships between seizure/epilepsy history and MRI findings were statistically analyzed. Moreover, clinical and imaging differences were evaluated between supratentorial and brainstem AGs. RESULTS: Intratumoral T1‐weighted high‐intensity areas, stalk‐like signs, and regional brain parenchymal atrophy were observed in 23 out of 50 (46.0%), 10 out of 50 (20.0%), and 14 out of 50 (28.0%) patients, respectively. Intratumoral T1‐weighted high‐intensity areas were observed significantly more frequently in patients with stalk‐like signs (positive, 9/10 vs. negative, 14/40, p = .0031) and regional atrophy (13/14 vs. 10/36, p = .0001). There were significant relationships between the length of seizure/epilepsy history and presence of intratumoral T1‐weighted high‐intensity area (median 3 years vs. 0.5 years, p = .0021), stalk‐like sign (13.5 vs. 1 year, p < .0001), and regional atrophy (14 vs. 0.5 years, p < .0001). Patients with brainstem AGs (n = 7) did not have a seizure/epilepsy history and were significantly younger than those with supratentorial AGs (median, 5 vs. 13 years, p < .0001, respectively). CONCLUSIONS: Intratumoral T1‐weighted high‐intensity areas, stalk‐like signs, and regional brain atrophy were frequent imaging features in AG. We also found that affected age was different between supratentorial and brainstem AGs.
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spelling pubmed-93068932022-07-28 Neuroimaging features of angiocentric glioma: A case series and systematic review Kurokawa, Ryo Baba, Akira Emile, Pinarbasi Kurokawa, Mariko Ota, Yoshiaki Kim, John Capizzano, Aristides Srinivasan, Ashok Moritani, Toshio J Neuroimaging Review Articles BACKGROUND AND PURPOSE: Angiocentric gliomas (AGs) are epileptogenic low‐grade gliomas in young patients. We aimed to investigate the MRI findings of AGs and systematically review previous publications and three new cases. METHODS: We searched PubMed, Elsevier's abstract and citation database, and Embase databases and included 50 patients with pathologically proven AGs with analyzable preoperative MRI including 3 patients from our institution and 47 patients from 38 publications (median age, 13 years [range, 2‐83 years]; 35 men). Two board‐certified radiologists reviewed all images. The relationships between seizure/epilepsy history and MRI findings were statistically analyzed. Moreover, clinical and imaging differences were evaluated between supratentorial and brainstem AGs. RESULTS: Intratumoral T1‐weighted high‐intensity areas, stalk‐like signs, and regional brain parenchymal atrophy were observed in 23 out of 50 (46.0%), 10 out of 50 (20.0%), and 14 out of 50 (28.0%) patients, respectively. Intratumoral T1‐weighted high‐intensity areas were observed significantly more frequently in patients with stalk‐like signs (positive, 9/10 vs. negative, 14/40, p = .0031) and regional atrophy (13/14 vs. 10/36, p = .0001). There were significant relationships between the length of seizure/epilepsy history and presence of intratumoral T1‐weighted high‐intensity area (median 3 years vs. 0.5 years, p = .0021), stalk‐like sign (13.5 vs. 1 year, p < .0001), and regional atrophy (14 vs. 0.5 years, p < .0001). Patients with brainstem AGs (n = 7) did not have a seizure/epilepsy history and were significantly younger than those with supratentorial AGs (median, 5 vs. 13 years, p < .0001, respectively). CONCLUSIONS: Intratumoral T1‐weighted high‐intensity areas, stalk‐like signs, and regional brain atrophy were frequent imaging features in AG. We also found that affected age was different between supratentorial and brainstem AGs. John Wiley and Sons Inc. 2022-02-24 2022 /pmc/articles/PMC9306893/ /pubmed/35201652 http://dx.doi.org/10.1111/jon.12983 Text en © 2022 The Authors. Journal of Neuroimaging published by Wiley Periodicals LLC on behalf of American Society of Neuroimaging. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review Articles
Kurokawa, Ryo
Baba, Akira
Emile, Pinarbasi
Kurokawa, Mariko
Ota, Yoshiaki
Kim, John
Capizzano, Aristides
Srinivasan, Ashok
Moritani, Toshio
Neuroimaging features of angiocentric glioma: A case series and systematic review
title Neuroimaging features of angiocentric glioma: A case series and systematic review
title_full Neuroimaging features of angiocentric glioma: A case series and systematic review
title_fullStr Neuroimaging features of angiocentric glioma: A case series and systematic review
title_full_unstemmed Neuroimaging features of angiocentric glioma: A case series and systematic review
title_short Neuroimaging features of angiocentric glioma: A case series and systematic review
title_sort neuroimaging features of angiocentric glioma: a case series and systematic review
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306893/
https://www.ncbi.nlm.nih.gov/pubmed/35201652
http://dx.doi.org/10.1111/jon.12983
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