Cargando…

Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon

INTRODUCTION: Human T-cell lymphotrophic virus type-1 (HTLV-1) and human immunodeficiency virus (HIV-1) co-infection occur in many populations. People living with HIV-1 and infected with HTLV-1 seem more likely to progress rapidly towards AIDS. Both HTLV-1 and HIV-1 are endemic in Gabon (Central Afr...

Descripción completa

Detalles Bibliográficos
Autores principales: Mouinga-Ondémé, Augustin, Boundenga, Larson, Koumba Koumba, Ingrid Précilya, Idam Mamimandjiami, Antony, Diané, Abdoulaye, Engone-Ondo, Jéordy Dimitri, Djuicy, Delia Doreen, Sica, Jeanne, Mombo, Landry Erik, Gessain, Antoine, Aghokeng Fobang, Avelin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307203/
https://www.ncbi.nlm.nih.gov/pubmed/35867643
http://dx.doi.org/10.1371/journal.pone.0271320
_version_ 1784752708636377088
author Mouinga-Ondémé, Augustin
Boundenga, Larson
Koumba Koumba, Ingrid Précilya
Idam Mamimandjiami, Antony
Diané, Abdoulaye
Engone-Ondo, Jéordy Dimitri
Djuicy, Delia Doreen
Sica, Jeanne
Mombo, Landry Erik
Gessain, Antoine
Aghokeng Fobang, Avelin
author_facet Mouinga-Ondémé, Augustin
Boundenga, Larson
Koumba Koumba, Ingrid Précilya
Idam Mamimandjiami, Antony
Diané, Abdoulaye
Engone-Ondo, Jéordy Dimitri
Djuicy, Delia Doreen
Sica, Jeanne
Mombo, Landry Erik
Gessain, Antoine
Aghokeng Fobang, Avelin
author_sort Mouinga-Ondémé, Augustin
collection PubMed
description INTRODUCTION: Human T-cell lymphotrophic virus type-1 (HTLV-1) and human immunodeficiency virus (HIV-1) co-infection occur in many populations. People living with HIV-1 and infected with HTLV-1 seem more likely to progress rapidly towards AIDS. Both HTLV-1 and HIV-1 are endemic in Gabon (Central Africa). We investigated HTLV-1 and HIV-1 co-infection in the Haut-Ogooué province, and assessed factors that may favor the rapid evolution and progression to AIDS in co-infected patients. METHODS: Plasma samples from HTLV-1 patients were tested using ELISA, and positive samples were then tested by western blot assay (WB). We used the polymerase chain reaction to detect HTLV-1 Tax/Rex genes using DNA extracted from the buffy coat of ELISA-positives samples. RESULTS: We recruited 299 individuals (mean age 46 years) including 90 (30%) men and 209 (70%) women, all of whom are under treatment at the Ambulatory Treatment Centre of the province. Of these, 45 were ELISA HTLV-1/2 seropositive. According to WB criteria, 21 of 45 were confirmed positive: 20 were HTLV-1 (44%), 1 was HTLV-1/2 (2%), 2 were indeterminate (4%) and 22 were seronegative (49%). PCR results showed that 23 individuals were positive for the Tax/Rex region. Considering both serological and molecular assays, the prevalence of HTLV-1 infection was estimated at 7.7%. Being a woman and increasing age were found to be independent risk factors for co-infection. Mean CD4+ cell counts were higher in HTLV-1/HIV-1 co-infected (578.1 (± 340.8) cells/mm(3)) than in HIV-1 mono-infected (481.0 (± 299.0) cells/mm(3)) Individuals. Similarly, the mean HIV-1 viral load was Log 3.0 (± 1.6) copies/ml in mono-infected and Log 2.3 (± 0.7) copies/ml in coinfected individuals. CONCLUSION: We described an overall high prevalence of HTLV-1/HIV-1 co-infection in Gabon. Our findings stress the need of strategies to prevent and manage these co-infections.
format Online
Article
Text
id pubmed-9307203
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-93072032022-07-23 Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon Mouinga-Ondémé, Augustin Boundenga, Larson Koumba Koumba, Ingrid Précilya Idam Mamimandjiami, Antony Diané, Abdoulaye Engone-Ondo, Jéordy Dimitri Djuicy, Delia Doreen Sica, Jeanne Mombo, Landry Erik Gessain, Antoine Aghokeng Fobang, Avelin PLoS One Research Article INTRODUCTION: Human T-cell lymphotrophic virus type-1 (HTLV-1) and human immunodeficiency virus (HIV-1) co-infection occur in many populations. People living with HIV-1 and infected with HTLV-1 seem more likely to progress rapidly towards AIDS. Both HTLV-1 and HIV-1 are endemic in Gabon (Central Africa). We investigated HTLV-1 and HIV-1 co-infection in the Haut-Ogooué province, and assessed factors that may favor the rapid evolution and progression to AIDS in co-infected patients. METHODS: Plasma samples from HTLV-1 patients were tested using ELISA, and positive samples were then tested by western blot assay (WB). We used the polymerase chain reaction to detect HTLV-1 Tax/Rex genes using DNA extracted from the buffy coat of ELISA-positives samples. RESULTS: We recruited 299 individuals (mean age 46 years) including 90 (30%) men and 209 (70%) women, all of whom are under treatment at the Ambulatory Treatment Centre of the province. Of these, 45 were ELISA HTLV-1/2 seropositive. According to WB criteria, 21 of 45 were confirmed positive: 20 were HTLV-1 (44%), 1 was HTLV-1/2 (2%), 2 were indeterminate (4%) and 22 were seronegative (49%). PCR results showed that 23 individuals were positive for the Tax/Rex region. Considering both serological and molecular assays, the prevalence of HTLV-1 infection was estimated at 7.7%. Being a woman and increasing age were found to be independent risk factors for co-infection. Mean CD4+ cell counts were higher in HTLV-1/HIV-1 co-infected (578.1 (± 340.8) cells/mm(3)) than in HIV-1 mono-infected (481.0 (± 299.0) cells/mm(3)) Individuals. Similarly, the mean HIV-1 viral load was Log 3.0 (± 1.6) copies/ml in mono-infected and Log 2.3 (± 0.7) copies/ml in coinfected individuals. CONCLUSION: We described an overall high prevalence of HTLV-1/HIV-1 co-infection in Gabon. Our findings stress the need of strategies to prevent and manage these co-infections. Public Library of Science 2022-07-22 /pmc/articles/PMC9307203/ /pubmed/35867643 http://dx.doi.org/10.1371/journal.pone.0271320 Text en © 2022 Mouinga-Ondémé et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mouinga-Ondémé, Augustin
Boundenga, Larson
Koumba Koumba, Ingrid Précilya
Idam Mamimandjiami, Antony
Diané, Abdoulaye
Engone-Ondo, Jéordy Dimitri
Djuicy, Delia Doreen
Sica, Jeanne
Mombo, Landry Erik
Gessain, Antoine
Aghokeng Fobang, Avelin
Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon
title Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon
title_full Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon
title_fullStr Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon
title_full_unstemmed Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon
title_short Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon
title_sort human t-lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural gabon
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307203/
https://www.ncbi.nlm.nih.gov/pubmed/35867643
http://dx.doi.org/10.1371/journal.pone.0271320
work_keys_str_mv AT mouingaondemeaugustin humantlymphotropicvirustype1andhumanimmunodeficiencyviruscoinfectioninruralgabon
AT boundengalarson humantlymphotropicvirustype1andhumanimmunodeficiencyviruscoinfectioninruralgabon
AT koumbakoumbaingridprecilya humantlymphotropicvirustype1andhumanimmunodeficiencyviruscoinfectioninruralgabon
AT idammamimandjiamiantony humantlymphotropicvirustype1andhumanimmunodeficiencyviruscoinfectioninruralgabon
AT dianeabdoulaye humantlymphotropicvirustype1andhumanimmunodeficiencyviruscoinfectioninruralgabon
AT engoneondojeordydimitri humantlymphotropicvirustype1andhumanimmunodeficiencyviruscoinfectioninruralgabon
AT djuicydeliadoreen humantlymphotropicvirustype1andhumanimmunodeficiencyviruscoinfectioninruralgabon
AT sicajeanne humantlymphotropicvirustype1andhumanimmunodeficiencyviruscoinfectioninruralgabon
AT mombolandryerik humantlymphotropicvirustype1andhumanimmunodeficiencyviruscoinfectioninruralgabon
AT gessainantoine humantlymphotropicvirustype1andhumanimmunodeficiencyviruscoinfectioninruralgabon
AT aghokengfobangavelin humantlymphotropicvirustype1andhumanimmunodeficiencyviruscoinfectioninruralgabon